摘要
在兔大脑中动脉阻断(MCAo)型局灶脑缺血动物模型上,我们观察了两种钙通道阻滞剂——尼莫地平、西比灵对缺血后24小时脑组织内Ca^(2+)积聚和脑水肿发展的影响。实验结果显示,尼莫地平对缺血脑的保护作用优于西比灵,使缺血灶内ca^(2+)积聚较对照组减轻50％,脑水肿减少38％,并有助于缓解Na^+/K^+紊乱。为钙通道阻滞剂应用于脑缺血、脑水肿的临床治疗提供了实验依据。
The neuroprotective effect of calcium channel blocker, nimodipine and sibelium, on rabbit MCAo model of focal ischemia was observed. The results showed that nimodipine 1mg/kg 30 min before and after the onset of ischemia significantly reduced brain water entered into the ischemic area by 38% and inhibited calcium accumulation by 50% as compared with vehicle treatment. Sibelium 0.1mg/kg had similar but milder effects. The clinical application of nimodipine and sibelium in the treatment of brain ischemia and brain edema was indicated.
出处
《上海医学》
CAS
CSCD
北大核心
1992年第7期402-404,共3页
Shanghai Medical Journal
基金
卫生部"七
五"攻关脑血管病专题基金资助
关键词
脑缺血
脑水肿
钙拮抗剂
Brain ischemia
nimodipine
sibelium
