摘要
目的 对不同厂家硝苯地平缓、控释片的释放度进行考察 ,为评定药品的质量提供依据。方法 以pH =3.0 75的磷酸盐缓冲液为溶出介质 ,用紫外分光光度法对 4个厂家的硝苯地平缓、控释片进行体外释放度测定和比较。结果 A、B、C片体外释放符合一级动力学 ,D片符合零级动力学。结论 均能达到缓、控释目的 。
Objective In order to provide principles to evaluate the quality of slow-release and controlled-release tablet of Nifedipine, which are from different manufacturers, study their vitro release rates.Methods In pH=3.075 phosphate buffer solution, test and compare with the vitro release rates of Nifedipine from different manufacturers by Ultraviolet Spectrophotometric method. Results A, B, C are fit for first-order kinetics, D is fit for zero-order kinetics.Conclusions Both dosage forms can reach the purpose of slowing or controlling the release of Nifedipine,and both can reduce dosing frequency.
出处
《广东药学》
2003年第5期25-26,共2页
Guangdong Pharmaceutical Journal
关键词
硝苯地平
缓、控释片
释放度
紫外分光光度法
nifedipine
slow-release tablet
controlled-release tablet
release rate
ultraviolet spectrophotometric method.
