期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胚胎干细胞诱导分化为神经细胞治疗帕金森病的前瞻与现状 被引量：7

Progression of embryonic stem cells in differentiating into neural cells and its application for the experimental therapy of Parkinson's disease
暂未订购
导出
摘要 帕金森病(Parkinson'sdisease,PD)为常见的中枢神经系统退行性疾病之一,其主要病理改变为中脑黑质多巴胺能神经元变性、缺失。胚胎干细胞(embryonicstemcells,ESc)是一种从早期胚胎分离、能在体外经抑制分化后无限增殖,高度未分化的全能干细胞。在全反式维A酸和无血清培养等诱导下,ES细胞可分化为神经元及神经胶质细胞等,为中枢神经退行性疾病的细胞移植治疗提供了丰富的种子细胞来源。将ESc分化为神经元移植治疗PD,在动物实验中已取得初步成效。
作者 唐军 曹娟 徐海伟 黎海蒂 吴旋
机构地区 解放军第三军医大学基础医学部生理教研室
出处 《中国临床康复》 CSCD 2003年第25期3503-3505,共3页 Chinese Journal of Clinical Rehabilitation
基金 国家自然科学基金资助项目(30070727)~~
关键词 帕金森病 胚胎干细胞 神经细胞 细胞分化 细胞移植
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献20

  • 1王涛,刘伟,崔磊,曹谊林.骨髓基质细胞诱导为神经原及胶质细胞[J].中国临床康复,2003,7(2):227-228. 被引量：21
  • 2阴金波,周政,杨辉,张可成,宋业纯.神经干细胞移植治疗帕金森病的实验研究[J].中国临床康复,2003,7(6):926-927. 被引量：17
  • 3吴旋,黎海蒂,李树浓,徐海伟,徐令.小鼠胚胎干细胞体外分化为神经前体细胞的研究[J].第三军医大学学报,2001,23(11):1260-1263. 被引量：8
  • 4Arenas E. Stem cells in the treatment of Parkinson' s disease. Brain Res Bul 2002; 57(6): 795 - 808.
  • 5Thomson JA, Itskovitz EJ, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysta. Sciences 1998;282(5391): 1145 -7.
  • 6Shamblot MJ, Axelman J, Wang S, et al. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA 1998; 95(23): 13726 -31.
  • 7Thomas SM. Transplantation of embryonic stem cells in Parkinson' s disease. Lancet Neurology 2002;1(1):6.
  • 8Rohwedel J, Kaomei G, Wobtm AM. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs 1999; 165(3 -4): 190 -202.
  • 9Dragger UC, Mccaffery P.Retinoic acid and development of the retina.Prog Retin Eye Res 1997;16:323 -51.
  • 10Okabe S, Nilssonk F, Spiro AC, et al. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev 1996; 59 ( 1 ) : 89 - 102.

二级参考文献10

  • 1[2]Sanchez RJ, Song S, Cardozo PF, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164(2): 247 -256
  • 2[3]Woodbury D, Schwarz EJ, Prockop DJ, et al. Adult rat and human bone marrow stromal cells differentiate into neurors. J Neurosci Res 2000;61 (4): 364 - 370
  • 3[4]Van der, Kooy D, Weiss S. Why stem cell. Science 2000; 287:1439 -41
  • 4[5]Lake JA, Rathjen J, Remiszewski J, et al. Reversible prognam-ming of pluripotent cell differentiation. J Cell Sci 2000; 113:55 -556
  • 5[6]Thomas K, Susanne M, Takanok H, et al. Metaplasia in traeptholial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis. Virchow Arch 2001; 438: 512-22
  • 6[7]Zhao ZL, Fu XB. Differenbial and modulating mechanism of cen on differei developmentel stage. Zhongguo Linchuang Kangfu(Chin J Clin Rehabil) 2002; 6(22):3412
  • 7[8]Fujita, Takumi Y, Eroek, et al. Successful preservation of human skin by vitffication. J Burn Care Rehabil 2000; 21 (4): 304 - 9
  • 8Zandstra P W，Biotech Bioeng，2000年，69卷，6期，607页
  • 9Xu L，Chin Sci Bull，2000年，45卷，8期，815页
  • 10张志军,王卫东,万琪,江文,王洪典.碱性成纤维细胞生长因子对缺血后脑组织新生神经元的影响[J].中国临床康复,2002,6(4):530-531. 被引量：11

共引文献41

同被引文献57

  • 1李英博,王莎莉.体外诱导人胚胎干细胞向神经细胞分化的研究进展[J].神经解剖学杂志,2004,20(6):633-636. 被引量：2
  • 2薛亚梅,王锋.胚胎干细胞向神经细胞定向诱导分化方法的研究进展[J].中国畜牧杂志,2005,41(8):58-61. 被引量：4
  • 3刘建中.胚胎干细胞体外诱导分化的研究进展[J].中国医药导报,2007,4(06X):8-9. 被引量：2
  • 4[4]Fan DS, Ogawa M, Fujimoto KI, et al. Behavioral recovery in 6-hydroxydopaminelesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Hum Geae Ther 1998; 9:2527 - 35
  • 5[5]Langston JW, Quik M, Petzinger G, et al. Investigating levodopa-induced dyskinesias in the parkinsonian primate. Ann Neurol 2000; 47:S79 - S89
  • 6[8]Carey RJ, Pinheiro-Carrera M, Dai H, et al. L-Dopa and psychosis: Evidence for L-Dopa-induced increases in prefrontal cortex dopamine and in serum corticosterone. Biol Psychiatry 1995; 8:669 - 6
  • 7[9]Monahan PE, Samulski RJ. AAV vectors: Is clinical success on the horizon? Gene Ther 2000; 7:24 - 30
  • 8[10]Elsworth JD, Taylor JR, Sladek JR, et al. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in Old-World primates one year after MPTP treatment. Neuroscience 2000; 95:399 - 408
  • 9[11]Parent A, Hazrati LN. Functional anatomy of the basal ganglia. The corticobasal ganglia-thalamo-cortical loop. Brain Res Rev 1995; 20:91 - 127
  • 10[12]Mandel RJ, Renddhl KG, Spratt SK, et al. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson' s disease. J Neuroscience 1998; 18:4271 - 84

引证文献7

二级引证文献15

中国临床康复
2003年 第25期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部