摘要
本文报告了用促红细胞生成素(EPO)皮下注射,每周3次治疗多发性骨髓瘤(MM)患者7例,骨髓增生异常综合征(MDS)5例。结果表明,EPO对MM患者的贫血有良好效果,用药5周血红蛋白平均升高20g/L,而对MDS患者的贫血无作用。皮下注射EPO无明显副作用。
Anemia is a common complicatlion of the patients with multiple myeloma (MM) and myelodysplastic syndrome (MDS). Most of the patients often require blood transfusion. 12 patients, including 7 cases of MM and 5 cases of MDS, were treated by rhEPO 10000U three times a week for 15 weeks. The hemoglobin in 6 of 7 cases of MM was steadily increased and eventually reached normal level without blood transfusion. The number of erythroid precursors in bone marrow was increased signifficantly and serum ferritin concentration was decreased gradually during administration of EPO. However, 5 patients with MDS had not any response to EPO. The adverse side effects were hardly observed in the patients treated with EPO. It is suggested that rhEPO is a promising tool for treating MM-associated anemia rather than MDS-associated anemia rather than MDS-associated anemia.
关键词
多发性骨髓瘤
骨髓增生异常
贫血
multiple myeloma
myelodysplastie syndrome
erythropoietin
anemia
