摘要
采用邻二氯苯和丁二酸酐为原料,经付氏酰基化反应,制得产物4 (3,4 二氯苯基) 4 氧代丁酸.研究催化剂的投入量,反应物配比,反应温度,反应时间对产率的影响,找出最佳反应条件为:催化剂为酰基化剂的2倍,丁二酸酐与邻二氯苯摩尔比为1∶6,反应温度为60℃,反应时间为4h,产物要在冰水体系中结晶析出.
4-(3,4-Dichlorophenyl)4oxobutanoic acid was made from 1,2dichlorobenzene and succinic anhydride by Frield-Crafts reaction. The study has obtained preferable condition of the reaction . The mole ratio of succinic anhydride to 1,2dichlorobenzen is 1∶6. The optimum temperature of the reaction is 60 ℃, and the reaction maintened at that temperature for 4 h ,then the product was crystalled in icewater system .The yield was 94 %.
出处
《沈阳化工学院学报》
2003年第3期168-170,共3页
Journal of Shenyang Institute of Chemical Technolgy
关键词
邻二氯苯
丁二酸酐
酰基化反应
1,2-dichlorobenzene
succinic anhydride
acylation
