摘要
目的 分析比较静脉应用立复欣 (利福霉素钠注射液 ) 3HR ZS(E) /9HR和口服利福平 3HRZS(E) /9HR的方案在肺外结核治疗中的作用。方法 选择经病理和 (或 )细胞学确诊的肺外结核患者 12 0例 ,按照随机原则将其分成对照组和实验组 ,实验组 6 2例用含静脉制剂立复欣全身加局部治疗 ,对照组 5 8例选用含口服利福平全身治疗加局部治疗的方案作为对照。结果 实验组和对照组治疗有效率 1个月分别为 38 7%、18 9% ,3个月分别为 5 9 7%、39 7% ,9个月分别为 80 6 %、5 8 6 % ,12个月治愈率分别为 96 8%、86 2 % ,两组比较差异有显著性 (P <0 0 5 ) ,而且实验组在疗程、肝功能的损害、体温恢复正常的时间等方面皆具有明显的优越性。结论 应用含立复欣的方案在肺外结核的治疗中具有局部药物浓度高 ,作用快 ,副作用小的特点 ,其治愈率高 。
Objective To analyze and compare the clinical e ffects and side effects between the regimes of 3HR *ZS(E) /9HR using rifamycin sodium injection in vein and taking rifampicin orally on treating extrapulmona ry tuberculosis. Methods 120 cases of extrapulmonary tuberculo sis diagnosed by pathology and/or cytology were selected and divided into the ex perimental group and the control group randomly. 62 patients in the experimenta l group were treated with rifamycin sodium injection through vein and locally, w hile 58 patients in the other group took rifampicin orally and some in local pla ce too, both with other drugs of 3HZS(E) /9H. Results The cure r ates of 1 month in the experimental group and the control one were 38 7% and 18 9% respectively; and those of 3 months and 9 months were 59 7%,39 7% and 80 6%,58 6% separately , which was statistically significant (P<0 05) betwe en them; those of 12 months had statistical significance too (P<0 05). More over the experimental group was obviously superior to the other on the course of treatment, lesion of liver function, recovery time of body temperature etc. Conclusion The regime of using rifamycin sodium injection on treati ng extrapulmonary tuberculosis has high cure rate, rapid progress, low side effe ct and high drug concentration in the focus. It can be widely used in clinical p ractice.
出处
《安徽医科大学学报》
CAS
2003年第5期380-382,共3页
Acta Universitatis Medicinalis Anhui
关键词
肺外结核
立复欣
利福平
治疗
临床对照研究
临床应用
rifamycins/therapeutic use
rifampicin/therapeutic use
case -control studies Free word extrapulmonary tuberculosis
