摘要
目的 发析比较静脉应用立复欣和口服利福平方案在颈淋巴结核治疗中的作用。方法 选择经病理和 /或细胞学确诊的颈淋巴结核患者 72例 ,随机将其分成对照组和实验组 ,实验组 37例用含静脉制剂立复欣全身加局部治疗 ,对照组 35例选用含口服利福平全身治疗加局部治疗的方案作为对照。结果 实验组和对照组有效率 1个月分别为 4 3.2 %、2 2 .9% ,3个月分别为 6 4 .9%、4 0 % ,治愈率 9个月分别为 86 .5 %、6 2 .9% ,两组比较差异有显著性 (P<0 .0 5 ) ,实验组 9个月与对照组 12个月治愈率分别为 86 .5 %、88.6 % ,两组比较差异无显著性 (P>0 .0 5 ) ,而且实验组在疗程、肝功能损害、体温恢复正常的时间等方面都具有明显的优越性。结论 应用含立复欣的方案在颈淋巴结核的治疗中具有局部药物浓度高、作用快、副作用小的特点 ,其治愈率高 ,有良好的临床应用价值。
Objective To analyze and compare the clinical effects and side effects between the regimes of 3HR* (R) ZS(E)/9HR which consisted of using rifamycin sodium injection in vein and taking rifampicin orally in the treatment of cervical tuberculous lymphadenitis patients.Methods Seventy-two cases of cervical tuberculous lymphadenitis diagnosed by pathology and/or cytology were selected and divided randomly into the experimental group and the control group. 37 patients in the experimental group were treated with rifamycin sodium injection through vein and local, whereas 35 controls took rifampicin orally, some in local place, both with other drugs of 3HZS (E)/9H. Results The 1-month cure rate for the experimental and the control groups were 43.2% and 22.9% respectively, and the 3-month rate for the two groups were 64.9%, 40% respectively, and the 9-month rates for the two groups were 86.5%, and 62.9%, respectively. All the group comparisons for the 1-month, 3-month and 9-month rates were statistically significant (P<0.05). The 12-month cure rate was not significantly different between the two groups (P>0.05). Moreover the experimental group was obviously better than the controls in the course of treatment, lesion of liver function, recovery time of body temperature, and so on.Conclusion The regime of using rifamycin sodium injection in treating cervical tuberculous lymphadenitis has high drug concentration in the local place, which results in higher cure rate, quicker concentration, and fewer side effects. It is of great value in the clinical practice.
出处
《临床肺科杂志》
2005年第1期15-16,共2页
Journal of Clinical Pulmonary Medicine
关键词
颈淋巴结核
立复欣
利福平
cervical tuberculous lymphadenitis rifamycin sodium injection rifampicin
