摘要
目的 研究重型肝炎患者红细胞CR1粘附活性的变化 ,探讨其与肝功能损伤严重程度的相关性。方法 采用红细胞天然免疫功能实验对 38例重型肝炎、5 8例慢性病毒性肝炎、30例正常人的红细胞CR1粘附活性进行测定 ,并与肝功能指标比较。结果 重型肝炎及慢性病毒性肝炎患者红细胞CR1粘附活性均低于正常人群 (P <0 .0 1) ,但重型肝炎患者红细胞CR1粘附活性下降的程度显著重于慢性病毒性肝炎患者 (P <0 .0 1) ;在疾病恢复期红细胞CR1粘附活性则明显回升 ;重型肝炎患者红细胞CR1粘附活性的变化与CHE、PT及PTA等指标的变化密切相关。结论 重型肝炎患者红细胞CR1粘附活性的变化与肝功能损伤严重程度密切相关 ,该项可作为分析重型肝炎患者病情严重程度、判断病情发展及预后的重要参考指标。
Objective To study the relationship between the activity of erythrocyte CR1 immune-adhering tumor cell and the severity of liver function in the patient with hepatitis gravis.Methods The assay of erythrocyte CR1 immune-adhering tumor cell was used in 30 cases of healthy individuals and 38 cases of patients with hepatitis gravis and 58 cases of chronic viral hepatitis. One tumor cell rounded by at least five red cells as a rosette, calculate the rations.Results The adhesion activity of ECR1 of patients with hepatitis gravis is obviously lower than that of healthy individuals and chronic viral hepatitis (P<0.01). The adhesion activity of ECR1 of hepatitis gravis is also obviously lower than that of chronic viral hepatitis (P<0.01). There is a significant relationship between the activity of ECR1 and the changes of CHE and PT, PTA in patents of hepatitis gravis. The activity of ECR1 will be significantly increased with the condition improved.Conclusion There is a significant relationship between the activity of ECR1 and the severity of liver dysfunction in the patient with hepatitis gravis. It is important to assay the activity of ECR1 in the patients with hepatitis gravis.
出处
《中国实验诊断学》
2003年第5期419-420,共2页
Chinese Journal of Laboratory Diagnosis
