摘要
目的 :检测盐酸吡格列酮的致畸毒性。方法 :应用Wistar大鼠进行致畸毒性试验。以6、24 ,96mg/kg3个剂量组给药。给药时间为大鼠妊娠后第6～15d。结果 :以96mg/kg剂量经口投与Wistar妊娠大鼠 ,吸收胎和死胎数增加 ,各剂量组对胎鼠均有生长发育迟缓的影响。 结论 :盐酸吡格列酮可产生明显的胚胎毒作用 。
Purpose: This study was undertaken to determine the potentially teratogenic effects of pioglitazone hydrochloride to Wistar rats. Methods: The study was conducted with three groups orally administered with 6, 24, and 96 mg/kg doses continuously for 10 days from 6th to 15th day after gestation of rats. Positive (2 mg/kg Dikushuang) and negative controls (0.5 % CMCNa) were performed at the same time with the method. Results: the number of absorptive embryo and dead fetus increased in the high dose group (96 mg/kg). The stunt effect of pioglitazone hydrochloride to the fetus was observed in all dose groups. Conclusion: Pioglitazone hydrochloride showed obvious embryo toxicity, but no teratogenic effect to fetus was observed.
出处
《癌变·畸变·突变》
CAS
CSCD
2003年第4期234-236,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
盐酸吡格列酮
大鼠
胚胎毒性
致畸作用
pioglitazone hydrochloride, Wistar rat, embryo toxicity, teratogenicity
