摘要
The synthesis of 5 methyl indole in only one step from p toluidine and ethylene exide was studied.The influence factors were investigated by experiments arragned by orthogonal design.The results show that the optimum conditions were:reaction temperature was 350℃;reaction time was 7g·h·mol -1 ;the molar ratio of p toluidine to water vapour to ethylene exide was 3∶8∶1;and the volume percentage of hydrogen in reaction mixture was 70%.The yield of 5 methyl indole was about 79%.
The synthesis of 5 methyl indole in only one step from p toluidine and ethylene exide was studied.The influence factors were investigated by experiments arragned by orthogonal design.The results show that the optimum conditions were:reaction temperature was 350℃;reaction time was 7g·h·mol -1 ;the molar ratio of p toluidine to water vapour to ethylene exide was 3∶8∶1;and the volume percentage of hydrogen in reaction mixture was 70%.The yield of 5 methyl indole was about 79%.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2003年第5期696-697,F003,共3页
Chemical Research and Application
