摘要
目的 观察牛磺酸 (Tau)对肾性高血压大鼠血浆及心肌血管紧张素 (Ang )、醛固酮 (Ald)的影响。方法 Wistar大鼠随机分为假手术组 (Sham组 )、二肾一夹肾性高血压模型组 (2 K1C组 )、Tau治疗组 (2 K1C+Tau组 ) ,每组 8只。测定并比较各组尾动脉收缩压 (SBP)、左心室重量指数 (L VWI)、心肌胶原含量、心肌纤维直径、血浆及心肌 Ang 、Ald含量。结果 2 K1C组大鼠 SBP、L VWI、心肌胶原含量、心肌纤维直径、血浆及心肌 Ang 、Ald含量较 Sham组显著增加 (P<0 .0 1)。牛磺酸 (5 0 mg/ kg· d)治疗 8周显著降低 2 K1C大鼠 SBP、L VWI、心肌胶原含量、心肌纤维直径、血浆及心肌 Ang 和 Ald含量 (P<0 .0 1)。结论 牛磺酸可降低肾性高血压大鼠循环及心肌局部肾素血管紧张素醛固酮系统 (RAAS)活性 ,抑制心肌细胞肥大及胶原增生 。
Objective To investigate effects of taurine on the AngiotensinⅡ(AngⅡ) and Aldosterone(Ald) concentration in plasma and myocardium in renovascular hypertensive rats. Methods Two kidney 1 clip (2K1C) rats were used to reestablish the model of renovascular hypertension.24 male Wistar rats were averagely divided into three groups at random: Sham group, 2K1C group and Tau treated group(50mg/kg.d,ig×8w) . The systolic blood pressure (SBP), left ventricular weight index (LVWI), myocardial collagen concentration, myocardial fiber diamension,AngⅡ and Ald content were determined. Results Compared with sham operated rats ,the SBP, LVWI, myocardial collagen concentration, myocardial fiber diamension,AngⅡ and Ald content in plasma or myocardium were significantly increased in 2K1C rats ( P <0.01). Taurine have an obvious suppressive effect on the above mentioned indices ( P <0.001). Conclusion Taurine whic effectively suppress myocardial cell hypertrophy and collagenous fiber productive reaction by decreasing plasma and myocardial local RAAS can produce good preventive effect on left ventricle hypertrophy caused by renal hypertension.
出处
《中国心血管杂志》
2003年第5期313-315,共3页
Chinese Journal of Cardiovascular Medicine
基金
湖北省教育厅重点资助课题 (编号 :2 0 0 1A40 0 6)
关键词
牛磺酸
肾性高血压
血管紧张素Ⅱ
醛固酮
左心室肥厚
Taurine
Renovascular hypertension
Angiotensin Ⅱ
Aldosterone
Left ventricle hypertrophy
