摘要
目的探讨法乐氏四联症（法四）病人心肌血管紧张素Ⅱ（ＡｎｇⅡ）、心钠素（ＡＮＰ）增龄性变化特征及其临床意义。方法用放免法测定３８例不同年龄法四及４０例小儿室间隔缺损病人右心耳ＡｎｇⅡ、ＡＮＰ含量。结果法四病人各年龄组心肌ＡｎｇⅡ、ＡＮＰ含量均高于对照组（Ｐ＜０．０５），其ＡｎｇⅡ含量与年龄呈显著正相关（ｒ＝０．７７８９，Ｐ＜０．０１），而ＡＮＰ含量则与年龄呈显著负相关（ｒ＝－０．７０５８，Ｐ＜０．０１）。结论法四病人心肌ＡｎｇⅡ、ＡＮＰ含量与年龄密切相关；ＡｎｇⅡ与ＡＮＰ平衡失调可能参与法四心肌继发性损害，应尽早手术矫正畸形。
Objective To elucidate the age related characteristics of myocardial angiotensin Ⅱ (Ang Ⅱ) and atrial natriuretic peptide (ANP) in patients with tetralogy of Fallot (TOF) and the clinical implication. Methods The contents of AngⅡ and ANP in right atrial appendages were determined by radioimmunoassay in 38 patients with TOF and 40 patients with small ventricular septal defect as control group with various ages. Results The contents of myocardial Ang Ⅱ and ANP in TOF patients were significantly higher than in control group ( P <0.05). The levels of myocardial Ang Ⅱ in the patients with TOF were positively correlated with age ( r =-0.7058, P <0.01). Conclusion Marked correlation was present between the levels of myocardial Ang Ⅱ and ANP in patients with TOF and their ages. The imbalance between Ang Ⅱ and ANP in myocardium of patients with TOF may result in the secondary myocardial damage. The corrective surgery should be performed as early as possible if it is feasible.
出处
《中华实验外科杂志》
CSCD
北大核心
1999年第4期356-357,共2页
Chinese Journal of Experimental Surgery
基金
湖北省自然科学基金
关键词
法乐氏四联症
心钠素
血管紧张素Ⅱ
年龄
Tetralogy of Fallot
Myocardium
Angiotension Ⅱ\ \ Atrial natriuretic peptide\ \ Age
