摘要
目的 :了解新生儿窒息后并发低钙血症发生的状况 ,探讨新生儿窒息后血钙变化与临床的关系。方法 :采用队列研究方法 ,对窒息组 (分为轻度、重度及宫内窘迫组 )和正常组的血液中总钙和游离钙浓度进行测定分析。结果 :窒息组与正常组总钙、游离钙比较 ,差异有极显著性 (P <0 .0 1) ,窒息组低钙血症者占 6 0 .9%。不同程度窒息组和正常组之间的总钙、游离钙比较差异有极显著性 ,用Dunnett法做各窒息程度组与正常组的总钙、游离钙的两者比较 (除轻度窒息组与正常组的游离钙比较P >0 .0 5 ,差异无显著性外 )差异有显著性。 15 6例窒息患儿中合并HIE 112例 ,随访 6～ 12个月 ,治愈 10 2例 ,后遗症 8例 ,死亡 2例。不同程度窒息合并HIE组和未合并HIE组四组之间总钙、游离钙的比较 ,用S -N -K法做各组的总钙、游离钙的两两比较 ,差异均有极显著性 (P <0 .0 1)。结论 :窒息程度愈重 ,血钙降低愈明显 ;血钙浓度愈低 ,组织器官损伤愈重 ,预后愈差。
Objective:to investigate the results of asphyxia of newborn associated with hypocalcemia;and to show the links between blood calcium fluctuations in asphyxia of newborn and clinic.Methods:there are two groups in our experiments.One is the asphyxia group in which 156 asphyxia of newborn patients were selected from our hospital and drawn 2ml femoral vein blood in the first day when they were in hospital.Another group is the normal group in which 50 healthy newborn were selected from obstetric department and drawn 2ml cord blood when they were just born.Then detect the levels of their total calcium and free calcium.Result:total calcium and free calcium in asphyxia group compared to those in the normal group are signifiantly different.Asphyxia group associated with hypocalcemia in all of the patients reaches 60.9%.Total calcium and free calcium in light asphyxia,severe asphyxia,intrauterine asphymia as compared to the normal group are respectively.Using Dunnett method,made pair comparison in every asphyxia group to the normal group (except for free calcium in light asphyxia group has no statistical significance to the normal group P >0.05),the rest comparisons have great significantly difference.The 156 patients including 112 associated with HIE.Total calcium and free calcium in asphyxia groups as compared to no HIE group,are greatly different.Using S-N-K method,made total calcium and free calcium pair comparison among every group.The difference reaches great significance.Conclusion:asphyxia is severer,hypocalcemia is more significant;and blood calcium is lower,organs are hurt severer,prognosis is poorer.
出处
《赣南医学院学报》
2003年第4期381-384,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
