摘要
目的 探讨孤啡肽 (OFQ)及单胺类递质与产后抑郁症的关系。方法 采用放射免疫法测定 2 5名健康产妇 (对照组 )及 17例产后抑郁症妇女 (抑郁组 )静脉血中孤啡肽及单胺类递质含量。结果 ①抑郁组及对照组血孤啡肽含量分别为 (2 7 39± 6 0 4 )ng/L及 (10 37± 3 6 5 )ng/L ,与对照组相比 ,抑郁组孤啡肽含量显著升高 (P <0 0 1) ;抑郁组及对照组血 5 羟色胺 (5 HT)含量分别为 (0 93± 0 2 1) μmol/L及 (1 4 3± 0 36 ) μmol/L ,二者间有显著差异 (P <0 0 5 ) ;抑郁组血多巴胺 (DA)含量为 (2 15± 0 4 1) μmol/L ,显著低于对照组 (P <0 0 5 )。②抑郁组孤啡肽与5 HT及DA含量呈显著负相关 (r为 0 6 0 1及 0 5 93,P <0 0 5 )。③抑郁组爱丁保产后抑郁量表总分 (EPDS)与OFQ含量呈显著正相关 (r为 0 5 12 ,P <0 0 5 ) ,与 5 HT、DA含量呈显著负相关 (r分别为 - 0 5 71及 - 0 5 2 6 ,P <0 0 5 )。结论 孤啡肽与产后抑郁症的发生发展密切相关。
Objective To explore the relationship between orphanin (OFQ) and monoamine neurotransmitters in the patients with postpartum depression (PPD). Methods 17 patients with postpartum depression (PPD group) and 25 healthy lying women (control group) were studied. The concentrations of plasma OFQ were measured by radioimmunoassay. The levels of 5-HT and DA were measured with high-pressure liquid chromatography with electrocheimcal detector. Results (1)The levels of plasma OFQ in PPD gruop and control group were (27.39±6.0) ng/L and (10.37±3.65) ng/L respectively, The level of OFQ in PPD group was significantly higher than that of the control grup ( P<0.01 ). The level of plasma 5-HT in PPD group was (0.93±0.21) μmol/L, significantly lower than that of the control group which was (1.43±0.36) μmol/L, The level of 5-HT in PPD grup decreased significantly ( P<0.05 ). The levels of plasma DA in PPD group was (2.15±0.41) μmol/L, which was signficantly lower than that of the control group (3.64±0.72) μmol/L. (2) In the PPD group, there was a significant negative correlation between the OFQ and monoamine neurotransmitters level ( P<0.05 ). (3) The levels of EPSDS were negatively correlated to 5-HT and DA( P<0.05 ), Significant correlation were found between the EPDS and OFQ ( P<0.05 ).Conclusions The PPD was associated with OFQ and monoamine neurotransmitters. The changes of OFQ levels may play an important role in the pathogenesis of the PPD.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2003年第5期321-322,共2页
Chinese Journal of Nervous and Mental Diseases
