摘要
目的：了解南北方地区产后抑郁症发病情况,综合分析性激素及神经递质与产后抑郁症的关系,为有效防治产后抑郁症提供依据。方法：根据选择标准,采用人工和系统的检索方法,对国内1994～2004年发表的有关性激素及神经递质与产后抑郁症的关系的病例对照研究文献进行定量综合分析。结果：南方地区产后1周抑郁症发病率为15.63%,95%CI（0.14,0.17）,合并P=0.0874;北方地区产后1周抑郁症发病率为7.66%,95%CI（0.05,0.08）,合并P=0.0252。南北方产后1周抑郁症发病率χ^2检验,P〈0.01。产后1周雌激素、多巴胺、去甲肾上腺素及5-羟色胺浓度明显低于对照组,产后1周与6周雌激素下降明显较对照组快,产后1周孕激素与孤啡肽水平高于对照组。结论：南方地区产后1周抑郁症发病率较北方高;产后抑郁症的发生与产妇血中雌激素、5-羟色胺、多巴胺、去甲肾上腺素浓度低有关,与血中孕激素、孤啡肽浓度高有关。
Objective To explore the and to comprehensively analyze the changes ship with postpartum depression. Methods changes of sex hormone and neurotransmitter collected by literature retrieval based on the incidence of postpartal depression in the south and north of sex hormone and neurotransmitter, and their relation- All published articles on case-control studies on the , and their relationship with postpartum depression were selection criteria. Meta-analysis was applied to evaluate the data in published papers from 1994 to 2004 in China. Results The incidence of postpartal depression in the south was 15.63 %. The combined P-valve 0. 17. The incidence of postpartum depression in the north was O. 0874, and 95% CI was 0. 14 to was 7.66%. The combined P-valve was 0. 0252, and 95% CI was 0.05 to 0.08. There was significant difference between the incidence of postpartum depression in the south and north （P 〈 0.01 ）. Estrogen and 5-HT in the plasma of the 1 st week after childbirth was obviously lower than the controls. Estrogen in the plasma of the 1 st week after childbirth and the 6 th week after childbirth decreased more quickly than the controls. Progesterone and orphanin FQ in the plasma of the 1 st week after childbirth were higher than the controls. Conclusion The incidence of postpartum depression in the south is higher than that of the north. Postpartum depression is related to the decrease in the plasma estrogen, 5-HT, dopamine,and noradrenaline, and to the increase in the plasma progesterone and Orphanin FQ.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2007年第3期460-465,共6页
Journal of Central South University ：Medical Science
基金
湖南省科技厅课题(05SK3109)~~
