摘要
目的 :本研究旨在了解基础脉压和随访 4年中脉压水平与脑血管病患者脑卒中再发事件的关系。 方法 :入选 15 2 0例 5年内曾发生过脑卒中 (包括脑出血和梗死 )和一过性脑缺血发作患者。平均年龄 (63 9± 7 6)岁。每半年至少随访 1次 ,随访 4～ 5年。随访中测量血压和收集脑卒中事件证据材料。终点事件评估委员会根据脑卒中证据材料评估脑卒中事件。收缩压 -舒张压 =脉压 ,脉压分 4级 ,即 <45 ,45～ 5 4,5 5～ 64 ,≥ 65mmHg (1mmHg=0 13 3kPa) ,分析不同级别脉压水平与脑卒中再发事件的关系。 结果 :入选患者基础脉压 <45 ,45～ 5 4,5 5～ 64 ,≥ 65mmHg者的脑卒中再发率分别为 9 7% ,12 7% ,16 1%和16 4% ;随访 4年中脉压平均水平 4个级别的脑卒中再发率分别为 8 6% ,14 7% ,17 5 %和 2 7 5 %。 结论 :脑血管病患者基础脉压或随访 4年中平均脉压与脑卒中再发密切相关 ,脉压越大 ,脑卒中再发危险越高。
Objective: To study the relationship of pulse pressure(PP)level at baseline and 4 years follow-up and the incidence of stroke recurrence in patients with cerebrovascular diseases. Methods: A total of 1 520 patients [mean age (63.9±7.6) years] with a history of stroke (cerebral infarction or haemorrhage) or transient ischaemic attack (TIA) within 5 years were enrolled in our study. Follow-up or visits were held at least every 6 months for 4-5 years. Blood pressure was measured and stroke event documentations were collected during the follow-up. An endpoint adjudication committee reviewed all the source documentations for those who had a stroke during follow-up. PP was defined as systolic blood pressure minus diastolic blood pressure. PP was divided into 4 grades as <45,45-54,55-64 and ≥65*!mmHg(1 mmHg=0.133 kPa). The correlation between PP grades and stroke recurrence was analyzed. Results: The incidence of stroke recurrence was 9.7%, 12.7%, 16.1% and 16.4% respectively for the baseline PP level of <45, 45-54,55-64 and ≥65 mmHg. The rates of stroke were 8.6%, 14.7%, 17.5% and 27.5% respectively in the 4 year follow-up period for the 4 grades. Conclusion: PP is closely related with stroke recurrence in patients with cerebrovascular disease. The greater the PP level, the higher the risk of stroke recurrence.
出处
《中国循环杂志》
CSCD
北大核心
2003年第4期284-287,共4页
Chinese Circulation Journal
