摘要
目的 :研究原发性高血压患者大动脉粥样斑块、内皮功能与内皮素 1和C 反应蛋白的关系。 方法 :选择 10 9例原发性高血压患者 ,其中男性 5 6例 ,女性 5 3例 ,平均年龄 (60 8± 6 2 )岁。应用B型超声对所有病例颈动脉、肱动脉进行扫查 ,检测颈动脉内膜中层厚度 (IMT)及粥样斑块 ,在静息、反应性充血时分别测量肱动脉内径 ,用免疫学方法测定血液中内皮素 1、C 反应蛋白浓度。然后分析超声结果与内皮素 1、C 反应蛋白浓度的关系。 结果 :随着IMT增厚 ,内皮素 1、C 反应蛋白浓度亦增大 ,各组之间差异均有显著性 (P <0 0 1) ,粥样斑块 1、 2、3级内皮素 1、C 反应蛋白浓度高于粥样斑块 0级 (P <0 0 5 )。加压充血后 ,肱动脉管径的内皮依赖性血管扩张(Flow MD)与内皮素 1、C 反应蛋白浓度呈负相关 ,相关系数分别是 -0 62 7、 -0 693 (P <0 0 0 1)。 结论 :原发性高血压患者血液中内皮素 1、C 反应蛋白浓度增高与肱动脉内皮细胞功能受损、颈动脉粥样硬化关系密切。
Objective: To explore the relationship of atherosclerosis and endothelial function with endothelin-1 and C-reactive protein in patients with essential hypertension. Methods: One hundred and nine patients with hypertension were selected, including 56 males and 53 females, [mean age (60.8±6.2) years]. B-mode ultrasound was used to scan carotid, brachial arteries of all patients in order to check and measure intima-media thickness(IMT), plaques of carotid arteries and diameter of brachial arteries at rest and during reactive hyperemia. Endothelin-1( ET-1 ), C-reactive protein(CRP) were determined with immunology method. The relation between results measured with ultrasound instrument and concentrations of ET-1, CRP was analyzed. Results: Positive correlation was found between concentrations of ET-1, CRP and IMT. Concentrations of ET-1, CRP were higher in plaque groups than those in non-plaque groups ( p <0.05). Negative correlation was found between flow-mediated dilatation ( Flow-MD,% ) and ET-1, CRP. The correlation coefficient was -0.627 and -0.693, respectively ( p <0.001). Conclusion: The increased concentrations of ET-1 and serum CRP were closely correlated with decreased endothelial function of brachial arteries and atherosclerosis of carotid arteries in patients with essential hypertension.
出处
《中国循环杂志》
CSCD
北大核心
2003年第4期288-291,共4页
Chinese Circulation Journal
