摘要
目的 :通过测定冠状动脉造影显示不同粥样硬化斑块形态患者血浆血管性血友病因子 (vWF)及α 颗粒膜蛋白(GMP 14 0 )水平 ,探讨其临床意义。 方法 :74例接受选择性冠状动脉造影的患者根据冠状动脉粥样硬化斑块形态分为光滑斑块组 (n =15 )、复杂病变斑块组 (n =3 7)和正常对照组 (n =2 2 )。所有患者于冠状动脉造影前采血测定血浆vWF、GMP 14 0水平。 结果 :复杂病变斑块组血浆vWF水平显著高于光滑斑块组 [(2 0 1 10± 2 0 92 ) %对 (14 9 40± 10 2 1) % ,P <0 0 1] ,复杂病变斑块组血浆GMP 14 0水平显著高于光滑斑块组 [(2 9 3 8± 3 17)ng/ml对 (17 5 4± 2 0 9)ng/ml ,P <0 0 1] ,均有极显著性差异。 结论 :冠状动脉造影表现为复杂形态病变者 ,血浆vWF、GMP 14 0水平高于光滑斑块病变者 ,可作为判断冠状动脉是否存在不稳定病变的间接参考。
Objective: To investigate the association of angiographic morphology of coronary atheroslerosis plaque with the plasma levels of von Willebrand factor(vWF) and α- granule membrane protein(GMP-140). Methods: Seventy-four patients undergoing selective coronary angiography (CAG)were divided into 3 groups based on the plaque morphology: Group S(n=15),concentric or eccentric stenosis with smooth borders;Group C (n=37),eccentric stenosis with complex borders;Group N (n=22),no coronary atheroslerosis on CAG.The plasma level of vWF and GMP-140 were determined by enzyme-linked immunosorbent assay(ELISA) before angiography. Results:The plasma level of vWF in group C was significantly higher than that of group S[vs(201.10±20.92)% vs(149.40±10.21)%,p<0.01].The plasma level of GMP-140 in group C was significantly higher than that of group S[( 29.38±3.17)*!ng/ml vs(17.54±2.09)*!ng/ml,p<0.01]. Conclusions: Angiographic coronary atheroslerosis with complex morphologic plaques is more unstable . Plasma levels of vWF and GMP-140 can be a predictive marker for the judgement of unstable lesions of coronary atheroslerosis.
出处
《中国循环杂志》
CSCD
北大核心
2003年第4期259-261,共3页
Chinese Circulation Journal
