摘要
目的通过观察冠心病患者冠状动脉粥样硬化斑块形态与血清肿瘤坏死因子(tumornecrosis factor-alpha,TNF-α)、内皮素(endothelin,ET)和白细胞介素6(Interleukin-6,IL-6)的关系,探讨斑块发生破裂的原因,进而为临床上防治不稳定斑块的破裂提供理论依据。方法测定经冠状动脉造影(Coronary angiography,CAG)确诊的230例“冠心病、心绞痛”患者以及230例CAG正常者的血清TNF-α,ET和IL-6水平,并比较其与不同冠状动脉斑块形态之间的关系。结果冠心病患者血清TNF-α,ET和IL-6水平明显高于正常对照组,2型斑块组血清上述指标水平显著高于1型3、型斑块组,且3型斑块组明显高于1型斑块组。结论冠状动脉粥样硬化的过程中有炎症反应参与,炎症因子TNF-α,ET和IL-6水平与冠状动脉病变斑块形态均是导致冠状动脉斑块破裂的重要因素。
Objective To investigate the relationship between tumor necrosis factor-alpha （THF-α）, endothelin （ET） and Interleukin-6 （IL-6） plasma level of coronary heart disease （CHD） patients and the type of the coronary plaque morphology. Methods Peripheral blood samples were taken from 230 CAG confirmed CHD patients and the same number of CAG normal patients. Serum THF-α, ET and IL-6 values were measured through enzyme-labeled immunosorbent assay （ELISA） technique in the 2 groups and their relationship between coronary plaque morphology were assesed. Results The mean levels of serum THF-α, ET and IL-6 in the CHD group were higher than those of the normal group （ P 〈 0.05）. The highest serum levels of the above inflammatory factors were found in type 2 plaque. The levels of THF-α, ET and IL-6 were higher in type 3 plaque compared with type 1 plaque. Conclusion Inflammation reaction may take part in the progress of atherosclerotic plaque and serum inflammatory factors such as THF-α, ET and IL-6 may reflect the plaque morphology.
出处
《中国介入心脏病学杂志》
2006年第3期183-185,共3页
Chinese Journal of Interventional Cardiology
基金
河南省科技厅资助项目(001170303)
