摘要
目的 :建立反相高效液相色谱法测定精神分裂症患者富马酸喹硫平血浓度的方法学 ,探讨其血浓度与患者年龄、性别、服药剂量及临床疗效的关系。方法 :采用高效液相色谱法测定 76例单一服用富马酸喹硫平的精神分裂症住院患者治疗前及治疗后第 2、4、6wk肘静脉血浓度 ,并进行BPRS量表评定及相关性分析。结果 :富马酸喹硫平血浓度在0 .0 5～ 0 .5mg·L-1范围内有良好线性关系 (r =0 .985 0 )。日剂量 5 0～ 4 5 0mg时血浓度随剂量增大而升高 ,但与服药患者年龄、性别无显著相关性。血浓度在 0 .12 6～ 0 .35 0mg·L-1范围内临床效果较好。结论 :测定方法简便、准确、专一性强 ,可用于富马酸喹硫平治疗药物监测。治疗窗浓度为 0 .12 6～0 .35 0mg·L-1。
AIM: To establish a method for determination of seru m concentrations of quetiapine fumarate in patients with schizophrenia of differen t doses and to study its relationship with clinical response. METHODS: A HPLC method was used to determine serum concentrations of quetiapine fu marate in 76 patients with schizophrenia before or after 2, 4, 6-week treatmen t and its therapeutic efficacies were measured by BPRS. RESULTS: The standard curve was linear within the concentration range of 0.05 - 0.5 mg·L -1 of quetiapine fumarate in serum (r= 0.9850 ). The serum concentrations of quetiapine fumarate were proportionally increas ed with the daily dose of 50-450 mg, but there was no significant correlation wi th age and sex. The optimal range estimated was 0.126 - 0.350 mg·L - 1 . CONCLUSION: The assay is simple, precise and suitable for therapeut ic monitoring of quetiapine fumarate and the optimal concentration window is 0 .126 - 0.350 mg·L -1 in treatment of patients with schizophrenia.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第6期627-630,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
药效学
富马酸喹硫平
血药浓度
高效液相色谱法
精神分裂症
pharmacodynamics
quetiapine fumarate
serum drug c oncentration
schizophrenia
chromatography
HPLC
