摘要
应用发色底物比色分析法,对42例正常人和52例急性白血病(AL)病人血浆组织纤溶酶原激活剂(t-PA)、组织纤溶酶原激活剂抑制剂(PAI)活性进行了检测.结果显示,初诊AL病人血浆t-PA活性较正常对照组显著升高(P<0.01),而PAI活性变化不显著;完全缓解期的AL病人,t-PA下降到正常范围;并发严重出血者,其t-PA活性和血小板计数与无出血者相比均有显著性差异(P<0.05);并发感染者,其PAI活性较非感染者及正常对照组均显著升高.提示血浆t-PA,PAI活性与AL病人不同的临床表现及其预后有关.
We detected plasma tissue plasminogen activator(t-PA)and plasminogen activator Inhibitor (PAI) activity in 52 patients with acute leukemia (AL) by a chromogenic substrate method. The results showed that in all the AL patients the plasma t-PA activity was elevated as compared with that of the control group, but the PAl activity was within normal range. It was noted that the platelet count was lower and the level of t-PA activity was higher in patients with serious bleeding than in patients without bleeding. This indicated that there were disorders in fibrinolysis and coagul ation in the patients with AL.
出处
《青岛医学院学报》
1992年第1期10-14,共5页
Acta Academiae Medicinae Qingdao Universitatis
