摘要
目的:研究血管内皮生长因子和微血管密度在涎腺腺样囊性癌的表达及其与侵袭、转移等生物学行为的关系。方法:采用SP免疫组织化学染色的方法对40例涎腺腺样囊性癌组织中MVD和VEGF进行检测。结果:肿瘤组织中VEGF阳性表达率70％(28/40),MVD均值为(51.2±6.6),显著高于正常涎腺组织(P<0.05);VEGF高表达组的平均MVD值明显高于低表达组的平均MVD值(P<O.05);VEGF、MVD高表达组的远处转移率明显高于VEGF、MVD低表达组(P<0.05)。结论:在涎腺腺样囊性癌组织中VEGF、MVD与肿瘤的远处转移呈正相关,二者可作为判定涎腺腺样囊性癌预后的指标之一。
Objective:To study the relationship between the expression of vascular endothelial growth factor and the microvessel density and invasion, metastasis in adenoid cystic carcinoma of salivary glands. Methods: Immunohistochemical staining( SP) was used to quantify MVD and VEGF expression in specimens from 40 patients with adenoid cystic carcinoma of salivary glands. Result: The positive expression rate of VEGF was 70% (28/40), the mean MVD was (51.2±6.6),the level of VEGF and MVD in adenoid cystic carcinoma of salivary glands was higher than in normal salivary glands tissue( P < 0.05) ; The mean MVD in case of high VEGF expression was significantly higher than those in cases of low VEGF expression( P < 0.05) . The distant metastasis rate in cases of high VEGF expression was significantly higher than those in cases of low VEGF expression( P < 0.05) . Conclusions: In adenoid cystic carcinoma of salivary glands, there is a significant positive correlation between MVD, VEGF and distant metastasis, MVD and VEGF may be served as a prognostic factor.
出处
《医学理论与实践》
2003年第9期1008-1009,共2页
The Journal of Medical Theory and Practice
