摘要
目的 探讨Cx32在胃癌癌前病变和胃癌组织中表达的动态变化。方法 B(a)P诱导小鼠前胃癌 ,免疫组织化学方法检测Cx32在小鼠前胃癌的发生、发展过程中表达的变化。结果 在胃癌发生、发展过程中 ,Cx32表达呈现一个由高水平到低水平表达直至无表达的梯度分布 ,即Cx32在小鼠正常前胃粘膜层中高水平表达 ,在不典型增生中表达明显减少或不表达 ,在胃癌组织中无表达。结论 Cx32基因表达的异常与胃癌的发生关系密切 ,Cx32表达降低或消失 ,导致胃粘膜上皮细胞间隙连接通讯障碍 ,胃粘膜细胞去分化并恶性增殖 ,最终发展为胃癌。
Objective To investigate the dynamic expression changes of connexin 32 in the precancerous lesions and forestomach neoplasia.Methods B(a)P was used to induce the forestomach neoplasia of the mice,and immunohistochemistry technique was used to detect the expression regularity of connexin 32 in the procedure of inducing forestomach neoplasia.Results The expression of connexin 32 manifested the gradient changes from high level to low level,and finally deletion.That is to say,expression of connexin 32 was highly level in the normal mucosa,obviously decreased or disappeared in the atypical hyperplasia mucosa,and had no expression in the cancer tissue.Conclusion The abnormal expression of connexin 32 gene had a close relationship with the stomach cancer.The reductive or deletive expression of connexin 32 caused the disorder of gap junctional intercellular communication in the mucosa,de-differentiation and malignant proliferation of cells,ultimately developed forestomach neoplasia.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第9期1057-1058,共2页
Chinese Journal of Public Health
基金
20 0 0年黑龙江省高校骨干教师创新能力资助计划项目
关键词
前胃癌
连接蛋白32
细胞间隙连接通讯
forestomach neoplasia
connexin 32
gap junctional intercellular communication
