摘要
目的 评价头孢地尼治疗呼吸系统、泌尿系统和皮肤软组织细菌感染的安全性和有效性。方法采用多中心随机对照试验。头孢地尼与头孢特伦均为 10 0 mg～ 2 0 0 mg tid,疗程 7～ 14 d。结果 头孢地尼组10 2例 ,头孢特伦组 10 6例 ,总痊愈率分别为 72 .5 5 %和 6 9.81% ,总有效率分别为 96 .10 %和 92 .4 5 %。呼吸系统痊愈率为 6 3.6 4 %和 72 .0 9% ,有效率为 90 .91%和 95 .35 % ;泌尿系统的痊愈率分别为 87.1%和 72 .73% ,有效率为 10 0 %和 90 % ;皮肤软组织的痊愈率分别为 70 .37%和 6 3.33% ,有效率为 10 0 %和 90 % ;细菌清除率分别为 89.0 1%和 94 .5 1%。两组的不良反应率为 7.2 6 %和 8.5 1%。统计学差异均无显著性。结论 头孢地尼治疗轻至中度的细菌性感染安全有效。
Objective To evaluate the clinical efficacy and safety of cefdinir in the treatment of acute bacterial infection. Methods Multicenter randomized controlled clinial study of cefdinir and cefteram were given at a dose of 100～200mg tid for 7～14 days. Results 208 patients enrolled in the study were divided into two groups, 102 cases were treated with cefedinir and 106 cases with cefteram as control. The cure rates of cefdinir and cefterom were 72.55% and 69.81%, the effective rates were 96.10% and 92.45% respectively. As for respiratory tract infection, the effective rates were 90.91% and 95.35%, cure rates 63.64% and 72.09%. For urinary tract infection, the effective rates were 100% and 90.91%, cure rates 87.10% and 72.73%; Skin and soft tissue infection, the effective rates 100% and 90% and cure rates 70.37%, 63.33% respectivly. Both agents were well tolerated, 7.26% and 8.15% of patients in the cefdinir and ceftream groups respectively experienced adverse events. There were no statistical significant difference. Conclusion Cefdinir is safe and effective in the treatment of slight and moderate bacterial infections.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2003年第9期555-561,共7页
Chinese Journal of Antibiotics
关键词
头孢地尼
头孢特伦
随机对照
细菌感染
Cefdinir
Cefteram
Randomized controlled
Bacterial infection
