摘要
目的 研究芪胆通痹汤对大鼠Ⅱ型胶原类风湿性关节炎 (RA)模型的作用机理 ,观察“清少阳、益肝肾”治法的疗效。方法 免疫学实验方法。结果 该方能有效减轻大鼠局部足肿胀程度及降低炎症组织中前列腺素 (PGE2 )含量 (P <0 0 1) ,并且具有镇痛作用 ;能显著抑制DNFB所致的小鼠DTH反应 (P <0 0 1)、抑制DTH小鼠脾脏T细胞增殖 (P <0 0 1) ,血清在 1∶2比例稀释下能显著抑制脾细胞IL 2的分泌 (P <0 0 1)。结论 芪胆通痹汤能有效缓解RA症状 ,并通过抑制Ⅳ型免疫变态反应治疗RA。
Objective To study the mechanism of the effects of Qidantongbi Decoction (QD) on rat type Ⅱ collagenous rheumatoid arthritis (RA) and observe the effecacy of the therapy for clearing the Shaoyang meridian and nourishing the liver and kidney. Method Immunological techniques were used in this experiment. Results QD could markedly reduce the degree of rat pedal swelling and the level of PGE 2 in inflammatory tissues ( P <0 01), exerting an analgesic effect at the same time. QD could also remarkably inhibit DTH induced by DNFB in the mouse ( P <0 01), T cell proliferation in the spleen of DTH mouse ( P <0 01), and IL 2 release of splenic cells ( P <0 01). Conclusion QD can effectively relieve RA symptoms and treat RA through inhibiting type IV immune allergic reaction.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2003年第5期39-41,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
教育部高等学校青年骨干教师资助计划项目
