摘要
本文研究了卡芬尼(CCA)治疗大鼠佐剂性关节炎(AA)的免疫调节机制。CCA 能使 AA大鼠低下的脾细胞刀豆素 A(ConA)反应、IL—2产生能力恢复正常,使外周血中减少的 Ts 细胞数目回升到正常水平,使 AA 大鼠腹腔 M(?)升高的 IL—1和 H_2O_2产生水平降至正常范围,还能明显减少 AA 大鼠炎性关节组织中 PGE_(?)的含量.研究 CCA 对体外正常大鼠淋巴细胞与 M(?)以及 AA 大鼠 M(?)功能的影响时发现,CCA 对 ConA 诱导的脾细胞增殖反应呈低浓度(0.1～1μg/ml)增强和高浓度(10μg/ml)抑制的双向作用;CCA(100μg/ml)对常大鼠腹腔 M(?)释放 H_2O_2无明显影响,但能显著减少 AA 大鼠腹腔 M(?)释放 H_2O_2.结果表明,CCA 对 AA 大鼠有明显的免疫调节作用,这种作用有明显的机能和剂量依赖性.CCA 对 AA 大鼠的治疗作用与其调整患鼠异常的免疫功能有关。
We have studied the immunoregulatory mechanisms of CCA on treating AA rats.In vivo,the lower response of splenocytes to ConA and decreased T-suppressor cells in peripheral blood were restored to normal by CCA given orally,but the elevated IL-1 synthesis,H_2O_2 release of peritoneal macrophages(PM(?)s)and PGE_2 production of inflamed joints were reduced by it.In vitro,ConA-induced splenocytes proliferation were enhanced with 0.1-1μg/ml of CCA,but diminished with 10μg/ml of it.CCA(100μg/ml)had no effect on H_2O_2 release of PM(?)s from normal rats,but it could reduce the H_2O_2 release from AA rats.In ummary,the therapeutic effect of CCA on AA rats were dependent on the original immune state of the rats and doses of CCA administerd.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1992年第2期114-119,共6页
Chinese Journal of Immunology
关键词
卡芬尼
免疫调节
RA
CCA
Carfenil
Rat adjuvant arthritis
Immunoregulation
