摘要
荷S_(180)肉瘤小鼠腹膜腔内注射银耳孢糖(TSP)200mg/kg·d×/d。在第3、5和7天注药后40分钟干荷瘤局部照射X射线5Gy。TSP和照射都能明显抑制肿瘤生长;二者合用的抑瘤率在停药后1、5、10天比照射组提高50.00％、32.52％、6.54%。TSP能提高荷瘤小鼠特別是受照鼠的脾重、脾有核细胞数和胸腺细胞~3H-TdR自发掺入率,并拮抗受照后NK细胞活性的下降。
Sarcoma 180 tumor cells were transplanted to subcutaneous tissue of the right hind leg of C57BL/6 mice. On day after transplantion, TSP was injected ip 200mg/kg per day for seven days. Mice in the group treated with TSP plus irradiation of local tumor (TSP + LI) were irradiated with 5 Gy X-ray for 40 minutes on 3rd, 5th and 7th day of TSP therapy. Marked tumor growth inhibition (TGI) effect was found in TSP-group or LI-group, being much more remarkable in the TSP + LI group. On d1, d5, and d10 after termination of the treatment, TGI rate of. TSP + LI group surpassed that of the group LI by 50.00%, 32.52%, 6.54% respectively. Moreover, TSP could also promote the immunity of tumor-bearing mice, especially in irradinted mice. It could increase the number of nucleated splenocytes, the weight of spleen, and the ~3H-TdR spontaneous incorporation rate of thymocytes. At the same time, it could also antagonize the decrease of NK cell activity on irradiation.
关键词
银耳孢糖
抑瘤作用
银耳
tremella fuciformis spores polysaccharides
Sarcoma 180
antitumor activity
mice
