摘要
目的 本课题为评估EB病毒血清学筛查鼻咽癌的前瞻性研究 ,并比较EB病毒血清学VCA /IgA阳性、阴性人群鼻咽癌的发病危险。方法 对中山市 30～ 5 9岁的 4 2 0 4 8人进行血清EB病毒VCA /IgA、EA /IgA检测等。所有人群随访至 1999年底。结果 筛查 13年阳性人群各年发病率始终高于阴性人群 ,平均发病率约为阴性人群的 2 0倍。筛查组、阳性随访组早期 (I、II)诊断率分别为 87.88%、83.33% ,显著高于医院门诊病人的 5 4 .4 1% (χ2 =2 8.6 2、χ2 =9.92 ,P <0 .0 1)。阴性组早诊率为 4 9.12 % ,与门诊组差异无显著意义 (χ2 =0 .6 2 ,P >0 .0 5 )。结论 VCA /IgA阳性人群在较长时期维持较高的患病危险 ,是筛查的重点 ;筛查的各种宣传手段可以有效地提高人群防癌意识 ;如以前报道 ,检测血清EB病毒抗体可以检出早期鼻咽癌。
Objective This prospective survey was aimed to evaluate the efficiency of Epstein-Barr viral serological test in detecting nasopharyngeal carcinoma (NPC) by comparing the NPC risks between serology-positive and serology-negative subjects. Methods Immunoenzymatic titration for VCA-IgA and EA-IgA was performed in 42,048 subjects between the ages of 30 and 59. All these subjects were followed up to the end of 1999. Results The annual incidence of NPC in VCA-IgA-positive subjects was higher than that in VCA-IgA-negative subjects during the 13 years all along. The NPC risk was 20-fold increase in VCA-IgA-positive subjects as compared to VCA-IgA-negative subjects .The detection rate of NPC in clinical early stages(I、II) in screening and serology-positive groups were 87.88% and 83.33% respectively, while in the out-patients it was 54.41% (χ 2 =28.62, χ 2 =9.92, P <0.01). There was no statistically significant difference in detecting clinical early stages between the NPCs of VCA-IgA- negative subjects (49.12%) and the out-patients (χ 2 =0.62, P >0.05). Conclusion The results suggest that in a relatively long period, a higher risk of NPC for VCA-IgA-positive subjects is expected, and they should have the priority for serology screening. To propagate the knowledge of screening for NPC helps to raise the general public's consciousness of NPC prevention. EBV serological examination could actually detect early-stage NPC.
出处
《肿瘤》
CAS
CSCD
北大核心
2003年第4期272-274,共3页
Tumor
基金
国家"七五"重点科技项目基金资助 (编号 :75 61 0 2 13 )
关键词
鼻咽癌
EB病毒
血清学筛查
中山市
Nasopharyngeal carcinoma
Epstein-Barr virus
Population Screening
