摘要
目的 探讨三氧化二砷(As_2O_3)对人乳腺癌裸鼠移植瘤的作用。方法 随机对照分组,连续7d尾静脉注射As_2O_3,观察As_2O_3对荷瘤鼠的作用。结果 As_2O_3 1.5mg·kg^(-1)·d^(-1)和3.0mg·kg^(-1)·d^(-1)组的抑瘤率分别为79.69％和78.18％;在电镜下肿瘤可见典型凋亡形态学改变,及肿瘤周围血管血栓形成;流式细胞术分析可见凋亡峰,凋亡率分别为 12.6％和 40.4％;未见明显造血系统功能受抑,差异有显著性(P<0.05)。结论 As_2O_3 对人乳腺癌裸鼠移植瘤具有抑瘤作用,且无明显毒副作用。
Objective To investigate the antitumor activity of arenic trioxide on a heterologous
graft model for human breast infiltrating duct carcinoma in nude mice. Methods The mice bearing tumor
were randomly divided into 4 groups. Arenic trioxide and cisplatin were injected via tail vein for 7 consec-
utive days. Results After the administration of arenic trioxide 1. 5 mg·kg^(-1)·d_(-1) and 3. 0 mg·kg_(-1)·
d_(-1), the growth of solid tumor was obviously inhibited with the inhibitory rate being 79. 69% and
78. 18% respectively. Under transmission electron microscopy, the cells of the solid tumor showed the
typically morphological characteristics of apoptosis and selective vascular shutdown. The sub-G1 peaks
were observed by flow cytometry on solid tumor specimen and the apoptic rate was 12. 6% and 40. 6%
respectively. The function of hematopoietic system wasn't inhibited. After the administration of cisplatin,
the growth of solid tumor was also obviously inhibited with the inhibitory rate being 54. 55%. Conclusion
Arenic trioxide has obvious antitumor activity on a heterologous graftmodel for human breast infiltrat-
ing duct carcinoma in nude mice. The side effects weren't obvious.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2003年第8期722-723,共2页
Chinese Journal of Experimental Surgery
基金
重庆市卫生局医学科研资助项目(01-2-047)
