摘要
目的 :对托吡酯 (妥泰 )作为加用和单用治疗癫痫的疗效、剂量、加量速度、起效时间及副作用等进行观察研究。方法 :10 7例癫痫患者 ,83例采用加用妥泰治疗 ,2 4例单用妥泰治疗。结果 :共有 10 0例患者完成了 13周疗程的观察。妥泰加用治疗有效率达 80 .2 % ,单用治疗达 79.1% ,妥泰加用治疗在儿童组有效率为 77.5 % ,成人组为 83.3% ,妥泰加用及单用治疗对各型癫痫均有效 ,妥泰起效时间与加量速度显著相关。妥泰起效时间在 4～ 8周达高峰。 10 7例患者 ,副作用发生率为32 .7% ,均较轻。结论 :妥泰加用及单用治疗癫痫均有较好疗效 ,是一种广谱、安全。
Objective: To observe and evaluate the therapeutical effect, dosage, velocity of dose escalation, time of begining to effect and the side effect of topiramate (TPM) both in mono therapy or add on therapy.Methods: 107 epileptic patients were observed, 83 of them were given TPM by add on therapy while 24 cases by TPM mono therapy. Results: 100 cases completed a course of 13 weeks' therapy. In add on therapy group, the effective rate of TPM achieved 80.2% in mono therapy group, it reached 79.1% . In children the effective rate of add on therapy was 77.5% and in the adult was 83.3% . It showed that both mono and add on therapy of TPM were effective to all of the seizure types. The time of begining to effect was related significantly to the velocity of dose escalation. The efficacy of TPM reached its peak after 4 8 weeks of treatment, side effects of this drug was minor and with a incidence of 32.7% . Conclusion: TPM had satisfactory therapeutic effect both in mono and add on therapy. It is a new broad spectrum, safe and well tolerated antiepileptic drug.
出处
《内科急危重症杂志》
2003年第3期126-129,共4页
Journal of Critical Care In Internal Medicine
