摘要
目的观察长期应用妥泰 (TPM)治疗各种类型癫痫的临床疗效、安全性及用药方法.方法采用自身对照方法,对146例各种类型的癫痫患者进行TPM合并用药(81例)和单药(65例)治疗,TPM从小剂量开始,起始量儿童＜20kg者为6.25mg/d,≥20kg者为12.5mg/d,成人为25mg/d,根据病情及不良反应,逐渐调整用药剂量.观察时间为1年～3年10个月,平均16.2个月,治疗20周后及1年后与基础期(入组前3个月)月发作频率进行比较.结果合并用药组治疗有效率为80.2%,单药治疗组有效率为87.7%,服药1年以上总有效率为90.4%.不良反应多发生在加量期,其中单药治疗组低于合并用药组,差异有显著性.结论 TPM是一种广谱有效及安全的新型抗癫痫药,可作为一线抗癫痫药,使用过程中应注意个人化原则.
Objective To evaluate the clinical efficiency and the reaction of topiramate （TPM） used long - term for various types of epilepsy and the way to administer the drug. Methods 146 cases with epilepsy were randomly assigned to 2 groups： Group A （n = 81） treated with routine antiepileptic combining with topiramate, while Group B treated only with topiramate. The dose of topiramate began with small amount, 6.25mg/d for child under 20 Kg in body weight, 12.5mg/d for child over 20Kg, and 25mg/d for adults. The dose was readapted according the status and untoward reaction respectively. The observation went on 1 year to 3 years and 10 months, average time was 16. 2 months. The frequency of epileptic attack 20 weeks and 1 year after treatment was compared with the frequency of basic stage 3 months before treatment. Results The effective rate was 87.8% and 80,2% in group B and group A respectively. The total average effective rate was 83.6% 1 year after treatment. Side effects often were found in the augmented dose period, and the rate in group B was less than that in group A. The difference between the two groups was significant. Conclusions TPM is a kind of new antiepileptic with the features of broad - spectrum, high performance and secure. The various conditions of different patients should be given more attention.
出处
《实用全科医学》
2005年第6期513-514,共2页
Applied Journal Of General Practice
关键词
妥泰
药物治疗
癫痫
用药剂量
Epilepsy
Topiramate
Long- term follow- up
Observation on curative effect
