摘要
目的 研究司帕沙星注射剂兔体药物动力学。 方法 10只日本大耳白兔静脉注射司帕沙星6 2mg/kg后 ,采用微生物法测定用药后不同时间血清药物浓度。 结果 该药的兔体药 时曲线符合二房室模型 ,AUC为 (5 6 8± 1 16 ) /h·L-1,消除半衰期为 (3 6 5± 0 95 )h。 结论 本文结果为司帕沙星临床合理用药提供了理论依据。
Objective To study the pharmacokinetics of sparfloxacin in 10 Japanese white rabbits.Methods The concentrations of sparfloxacin in serum were measured with the improved microbiologic method after the rbbits were injected iv 6.2mg/kg.The data were processed with 3P97 program.Results The concentration-time curves of sparfoxacin was fitted to the two-compartment open model.The AUC were(5 68±1 16)mg·h·L -1 ;t 1/2β were (3 65±0 95)h;Conclusion This paper provides a therotical basis for clinical trials.
出处
《医药论坛杂志》
2003年第16期35-36,共2页
Journal of Medical Forum
关键词
司帕沙星注射
药物动力学
微生物法
兔
sparfloxacin
pharmacokinetics
microbiologic method
rabbit
