摘要
目的 :为了研究肺癌病人胸腔积液中α2 -巨球蛋白 (α2 -M)含量的变化 ,分析其与肺癌发展、转移的关系 ,探讨肺癌胸腔积液诊断的新方法及恶性胸腔积液治疗的新思路。方法 :采用免疫浊度法分别测定了肺癌病人、肺结核病人胸腔积液和漏出性胸腔积液中α2 -M的含量 ,并对测定结果进行统计学处理。结果 :肺癌病人胸腔积液中α2 -M的含量较肺结核病人胸腔积液中的含量有显著降低 (P <0 .0 0 1) ,而漏出性胸腔积液中α2 -M的含量与结核性、肺癌性胸腔积液相比较有显著性降低(P <0 .0 0 1,P <0 .0 5 )。结论 :肺癌病人胸腔积液中存在α2 -M的代谢紊乱。监测胸腔积液中α2 -M的含量有利于良性、恶性胸腔积液的鉴别诊断。使用α2 -M制剂可能有助于抑制恶性肿瘤的发展、有利于恶性胸腔积液的治疗。
Objective: In order to study the changes of α 2-macroglobulin(α 2-M) in lung cancer patients with pleural effusion and analyze the relationship between the neoplasm growth and transplant and α 2-macroglobulin. And to discuss the new methods of diagnosis and the new treatment for malignant pleural effusion. Methods: The pleural fluid content of α 2-M of patients with lung cancer, patients with tuberculosis and patients with transplant have been detected by the methods of immuno-nephelometry. The results were analysed statistically . Results: The content of α 2-M in pleural effusion of lung cancer was lower than that in tuberculous pleural effusion, Thus, the content of α 2-M in transudate compared with the content of tuberculous and malignant pleural effusion, it was significant different(P<0.001,P<0.05).Conclusion: The experimental results indicated that: There was pathological metabolism of α 2—M in pleural effusion of lung cancer. There will be helpful in the differential diagnosis of pleural effusion. Using the products of α 2—M may be helpful in controlling the development of neoplasm and treatment of malignant pleural effusion.
出处
《河北医学》
CAS
2003年第7期596-598,共3页
Hebei Medicine
关键词
肺肿瘤
Α2-巨球蛋白
结核
胸腔积液
Lung
Neoplasms
α 2-Macroglobulin
Pleural
Effusion
Tuberculosis
