摘要
应用烯基膦亚胺 ( 1)与芳基异氰酸酯的氮杂Wittig反应 ,得到的碳二亚胺 2再与醇在醇钠催化下反应 ,合成了新的 2 烷氧基 4H 咪唑啉 4 酮衍生物 ( 3 ) .探讨了成环反应的条件以及所合成的新型杂环化合物的杀菌活性 ,结果表明部分化合物表现出较好的抑菌活性 ,其中以 3b活性最好 ,在 5 0mg/L浓度时 ,对水稻纹枯菌和苹果轮纹菌的抑制率达 81%以上 .
Carbodiimides 2, obtained from aza-Wittig reaction of vinyliminophosphoranes ( 1) with aromatic isocyanates, reacted with ROH in the presence of catalytic amount of sodium alkoxide to give new 2-alkoxy-4H-imidazolin-4-ones (3). The conditions for cyclization and the fungicidal activities of the new heterocycles synthesized were optimized. The results showed that some of the compounds exhibited good fungicidal activities. The best one was compound 3b, which exhibited more than 81% inhibition of Pellicularia sasakii and Physalapora piricola at 50 ng/L.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2003年第8期818-821,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金 (No.2 0 1 0 2 0 0 1 )资助项目 .
