摘要
研究了原子吸收光谱法间接测定氢溴酸山莨菪碱。在溶液pH为 5 1～ 5 3,当四苯硼钠过量时可完全沉淀氢溴酸山莨菪碱 ;加入过量的氯化钾沉淀滤液中剩余的四苯硼钠 ;干过滤 ,用原子吸收分光光度计在76 6 5nm波长下测定滤液中过量的钾 ,因四苯硼钠与氢溴酸山莨菪碱和氯化钾均按 1∶1的计量关系生成沉淀 ,可以直接计算得到氢溴酸山莨菪碱的含量。对氢溴酸山莨菪碱注射液进行了测定 ,测定结果准确。方法简单快速 ,回收率在 96 %～ 10 3%之间 ,相对标准偏差为 1 4 %。该方法可进一步推广原子吸收光谱法在其他相关药物测定方面的应用。
A method for indirect determination of anisodamini hydrobromidum by atomic absorption spectroscopy (AAS) was studied. At pH 5.1-5.3, the anisodamini hydrobromidum was completely precipitated by excessive sodium tetraphenylborate, and the surplus was precipitated by excessive potassium chloride. Because both anisodamini hydrobromidum and potassium chloride are precipitated by sodium tetraphenylborate respectively according to the ratio of 1∶1, the potassium in filtrate was detected by AAS at the wavelength of 766.5 nm to calculate the content of anisodamini hydrobromidum. The sample of injection anisodamini hydrobromidum was determined and the results were satisfactory. The recoveries of anisodamini hydrobromidum ranged from 96%-103% and the relative standard deviation (RSD) was less than 1.4%. The method can be used to determine other related medicine samples.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2003年第4期825-826,共2页
Spectroscopy and Spectral Analysis
