摘要
目的 :探讨垂体瘤中抑癌基因 pten编码产物的表达情况及临床病理意义。方法 :应用免疫组织化学技术检测 36例垂体肿瘤及 6例正常脑组织中 PTEN蛋白的表达情况。 结果 :对照组 6例正常脑组织 PTEN表达全部阳性 ,强阳性率为83.3% (5 / 6 ) ;2 8例非侵袭垂体瘤中 PTEN的阳性表达率为 78.5 % (2 2 / 2 8) ,强阳性率为 35 .7% (10 / 2 8) ,阳性信号存在于胞质中 ,与正常对照组比较强阳性率差异有统计学意义 (P<0 .0 5 ) ;而 8例侵袭性垂体瘤 (包括 1例垂体癌 )中 PTEN无强阳性表达 ,阳性率为 2 5 .0 % (2 / 8) ,与正常对照组及非侵袭性垂体瘤比较皆有显著性差异 (P<0 .0 1)。 结论 :垂体瘤的发生发展中存在 pten基因的失活现象 。
Objective:To investigate the protein expression of tumor suppressor gene pten in pituitary tumor.Methods:A total of 36 cases of pituitary tumor tissues and 6 cases of normal brain after brain trauma surgery were analyzed for PTEN protein expression by immunohistochemical method.Results:The strong positive rate was 83.3%(5/6) in normal brain and 35.7%(10/28) in 28 cases of non invasive pituitary tumor.There was significant difference between them in the pattern of PTEN protein expression( P <0.05).The positive rate was 100.0% in normal brain and 25.0%(2/8) in 8 cases of invasive pituitary tumor and pituitary carcinoma.There was significant difference between them in the pattern of PTEN protein expression( P <0.01).Conclusion:It is indicated that pten gene inactivation may play a role in the genesis and development of pituitary tumor.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第8期847-849,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金 ( 3 9670 73 3 )
