摘要
合成一种新的 β-环糊精衍生物固定相 :3 -单 ( N-苯甲酰化 L-丙氨酸酰基 ) -七 ( 2 ,6-二-0 -甲基 ) -β-环糊精 ,考察了该种固定相的气相色谱性能 ,并与合成中使用的母体七 ( 2 ,6-二 -0 -甲基 ) -β-环糊精衍生物的气相色谱性能进行了比较。新固定相具有较好的成膜性 ,较高的柱效 ,对难分离的含有苯环的常规物质对以及含苯环的位置异构体具有很好的分离效果。氨基酸官能团的引入改变了环糊精的空腔结构 ;环糊精上取代基的大小、极性、形状与客体分子的 π-π相互作用等对于客体分子的识别起到关键作用。
A kind of new cyclodextrin derivative (CD), 3-mono-O-(N-benzoyl-L-lactamyl)-heptakis(2,6-di-O-methyl)-β-CD was synthesized and used as capillary GC stationary phase. The separation properties of the kind of new CD was investigated compare with their matrix heptakis(2,6-di-O-methyl)-β-CD, showing that they all possess good filmforming properties and high column efficiency and fine separation abilities to disubstituted benzene isomers. The results also indicate that many factors, including cyclodextrins cavity, substituted groups, the polarity, the size and π-πinteractions, played an important roles in the separation of positional isomers.
出处
《云南师范大学学报（自然科学版）》
2003年第5期47-50,共4页
Journal of Yunnan Normal University:Natural Sciences Edition
基金
云南省科委基金资助项目 ( 2 0 0 0 B0 0 45 M)
