摘要
本文运用单克隆抗体免疫荧光法测定34例中晚期肺癌患者,在接受首次选择性肺动脉化疗栓塞治疗后的外周血淋巴细胞亚群变化,并与20例正常人作对照。结果发现:①中晚期肝癌患者的OKT_3,OKT_4,NKH-1表面标记阳性细胞数明显低于正常人(P<0.001),但OKT_3亚群无差异(P>0.05);②介入治疗后,T 淋巴细胞未见明显变化;③NKH-1表面标记阳性细胞数在术后1周有下降趋势,但P>0.05,术后1月显著下降(P<0.01).本文讨论了肝癌介入治疗对细胞免疫功能的影响、可能的机理和介入期间进行细胞免疫监测的意义.
Fluorescence immunoassay wasused to test the subsetes of lympho-cytes(OKT_3,OKT_4,OKT_8,NKH-1)in 20 normal persons and 34 patientswith advanced primary liver cancer(PLC)during their first treatment:with selective hepatic arterial infusionand embolization.The results showed:1.The relative numbers of OKT_3,OKT_4,and NKH-1 surface markercells in the patients with advancedPLC are significantly lower than thatin the control group(P<0.001),butthe numbers of OKT8 have not signi-ficant differanee(P>0.05);2.No si-gnificant change was found in T-lym-phocyte groups after the interventi-onal management;3.The numbers ofNKH-1 surface marker cells inclinedto decrease(P>0.05)at one week afterthe management and decreased obvi-ously after one month.The results su-ggest that the interventional treatmentwill affect cellular immunity of theadvanced PLC patients in some degree.The authors,consider that it is neces-sary to monitor the immuno-functionof the patients,and to give suitableimmunotherapy during the interventi-onal treatment.
出处
《临床放射学杂志》
CSCD
北大核心
1992年第1期38-42,56,共5页
Journal of Clinical Radiology
