摘要
对１００例ＬＰ一ＴＡＥ治疗后的肝细胞肝癌通过ＣＴ扫描和肝功能检查追踪观察３～１２月，发现多数病人肝脏形态和功能发生明显损害。根据ＣＴ扫描观察，Ｌｐ一ＴＡＥ治疗前３５例无肝硬变表现，治疗后２５例出现肝硬变；Ｌｐ一ＴＡＥ术前６５例已有肝硬变，术后４５例ＣＴ表现肝硬变加重。按照Ｃｈｉｌｄ′ｓ肝功能分级标准，１００例肝癌ＬＰ一ＴＡＥ后肝功能下降的总体发生率为６６％，其中Ａ→Ｂ级４１例，Ａ→Ｃ级１５例，Ｂ→Ｃ级１０例，无变化２７例，好转７例。如果仅以ＡＬＢ评价肝功能，则１００例中９３例肝功能均有不同程度损害。肝功能损害与碘油用量、治疗次数、是否用明胶海绵栓塞及治疗后肝动脉是否通畅密切相关。文中详细讨论了肝脏受损的临床意义与发生机制，并提出今后Ｌｐ一ＴＡＥ的治疗原则。
patients with HCC treated with Lp-TAE were followed up with CTand hepatic function tests Postoperatively,25 of 35 was demonstrated cirrhosis changes onCT which were not obvious preoperatively,and 45 of 65 caseS who had displayed the chan-ges on CT preoperatively showed increase of severity.According to Child′s system,66 casesshowed deterioration of liver funtion:grade A→B n=41; A→C,n=15 and B→C,n=10,while 27 cases showed no alteration and 7 cases improvement.If serum albumin was used asan indicator of liver function ,Nin ty three perant of these patients revealed dysfunction asthe albumin level lo wered in them The dysfunction is closely related to the total dose of iod-ized oil the number of treatment gelftoam sponge particles and the postoperative patency ofthe hepatic artery. The pathogenesis of the impairment of liver function is discussed, andthe treatment principle of Lp-TAE are proposed.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1994年第1期50-53,共4页
Chinese Journal of Cancer
关键词
肝肿瘤
肝硬变
肝功能
栓塞
Hepatocellular carcinoma Hepatic function Cirrhosis Chemoembolza-tion
