摘要
目的 分析不同严重度的阿尔茨海默病(AD)患者的认知缺损特征。方法 符合DSM-Ⅳ与NINCDS-ADRDA制定的可能AD诊断标准的AD患者68例,其中轻、中、重度AD分别为27、25和16例。选择正常老人69例作为对照组。采用简明精神状态量表(MMSE)和ADAS-cog评定认知功能。结果 轻度AD组的ADAS-cog总分平均19分,中度AD组34分,重度AD组为46分,ADAS-cog总分变化比MMSE总分能更精确地反映AD患者认知功能的变化。根据项目分变化分析,轻一中度AD以记忆损害为主,重度以语言损害为主。记忆损害在中一重度期间有一个平台期,衰退减速。结论 ADAS-cog可以有效地反映AD的认知缺损,这使它可以作为抗痴呆药物疗效的判定工具,但它的缺点(如被试必须有一定的阅读能力)限制了它在国内的推广应用。
Objective To analyze cognitive function impairment of different severity Alzheimer's disease and opplicability of the Chinese version of Alzheimer's Disease Assessment Scale- Cognitive Subtest (ADAS-cog) . Methods According to the criteria of DSM- W and NINCDS-ADRDA, 68 patients diagnosesed as probable cases of Alzheimer's disease were studied. 69 normal elderly and 27 mild AD, 25 modest AD, 16 severe AD were evaluated using cranial CT or MRI and using mini-mental state examination(MMSE) and ADAS-cog. Results Cognitive function change was assessed by ADAS?cog more accuracy than MMSE. Memory impairment was most importance in patients with mild AD. Language function impairment became principal in severe AD. But the decline of memory was not apparent in modest and severe AD , existed a plainness period. Conclusions ADAS-cog was useful as a clinical instrument to evaluate the severity of Alzhemer's disease,but the disadvantage limited to apply in our country,such as,subject must provided with reading ability.
出处
《神经疾病与精神卫生》
2003年第4期251-253,共3页
Journal of Neuroscience and Mental Health
