摘要
目的 :探讨E cadherin、CD44V6和HLA DR抗原在非小细胞肺癌组织中的表达及其临床意义。方法 :采用免疫组化ABC法 ,检测 6 5例原发性非小细胞肺癌组织中E cadherin、CD44V6和HLA DR抗原表达情况 ,并分析了其表达与肺癌临床病理的关系。结果 :6 5例肺癌组织中E cadherin、CD44V6和HLA DR的阳性表达率分别为 5 3 8%(35 /6 5 )、5 8 5 %(38/6 5 )和5 3 8%(35 /6 5 )。E cadherin、CD44V6表达与组织学类型无明显相关 ,与肺癌淋巴结转移密切相关。HLA DR与组织学类型明显相关 ,与肺癌有无淋巴结转移无明显相关性。E cadherin、CD44V6和HLA DR阳性表达与病理分级及临床分期密切相关。结论 :E cadherin、CD44V6和HLA DR异常表达在肺癌发生、发展和转移过程中起着重要作用 ,联合检测对判断肺癌生物学行为具有重要意义。
Objective:To explore the expression of E-cadherin,CD44V6 and HLA-DR in non-small cell lung cancer tissues and its clinical significance.Methods:Paraffin embedded tissues from 65 cases with non-small cell lung cancer were observed for expression of E-cadherin,CD44V6 and HLA-DR by immunohistochemistry (ABC method), the relationship between these expression and clinical pathology feature was analyzed.Results:The positive expression rate of E-cadherin,CD44V6 and HLA-DR in lung cancer was 53.8%(35/65),58.5%(38/65) and 53.8%(35/65) respectively. The expression of E-cadherin and CD44V6 were closely related to lymph node metastasis, no related to histological typing. Lung cancer with lymph node metastasis showed no higher expression of HLA-DR than lung cancer without lymph node metastasis. There was a distinct statistic difference between HLA-DR in adenocarcinoma and squamous cell carcinoma. The expression of E-cadherin,CD44V6 and HLA-DR was closely related to pathological grading and clinical stage.Conclusion:Expression of E-cadherin,CD44V6 and HLA-DR played an important role in the genesis,development and metastasis of lung carcinoma. Combined determination might be an important significance for judging biological behavior.
出处
《临床肿瘤学杂志》
CAS
2003年第4期251-253,256,共4页
Chinese Clinical Oncology
