摘要
目的:探讨N-三甲基壳聚糖(TMC60)对阿昔洛韦(ACV)凝胶的透皮吸收促进作用。方法:配制三种ACV凝胶,即不含促渗剂的阴性组,含3%薄荷醇的阳性组,含3%TMC60的TMC60组。用Franz扩散池,对三种凝胶的体外透皮程度及速度进行考察。结果:三种ACV凝胶体外透皮吸收的累积透过量Q与时间t呈现线性关系,且TMC60组和阳性组的稳态透皮速率J均大于阴性组(P<0.05),而两者间无明显差异(P>0.05)。结论:与同浓度薄荷醇相比,TMC60有相似的透皮吸收促进效果,值得进一步研究。
Objective： To study the penetration enhancement of N-trimethyl ehitosan （TMC60） in acyclovir （ACV） gel in vitro. Method： Three kinds of ACV gels were prepared, those were negative group without any enhancer, positive group with 3% menthol as the enhancer and TMC60 group with 3% TMC60 as the enhancer. The Franz diffusion cells were employed to study the penetration amount and rate of the ACV gels in vitro. Result： Accumulation penetration amount （Q） had linear relationship with time in ACV gels. Compared with that of negative group, stable-state penetration rates （J） of TMC60 group and positive group were both significantly increased （P 〈 0. 05） while there was no notable difference between the latter two groups （ P 〉 0. 05 ）. Conclusion： TMC60 has the similar enhancement compared with menthol and is valuable to be studied further.
出处
《中国药师》
CAS
2011年第5期656-658,共3页
China Pharmacist
