摘要
目的 :探讨慢性肾小球肾炎非尿毒症期患者体内一氧化氮 (NO)的变化 ,及其与血压的关系。方法 :应用化学比色法 ,测定 92例慢性肾炎非尿毒症期患者及 31例正常人的血清、尿NO-3 /NO-2 变化。结果 :慢性肾炎非尿毒症期患者血清及尿NO-3 /NO-2 水平较对照组显著降低 (P <0 .0 1) ;慢性肾炎非尿毒症期患者高血压组血清及尿NO-3 /NO-2 水平显著低于血压正常组及正常对照组 ,血压正常组尿NO-3 /NO-2 水平显著低于正常对照组 (P <0 .0 5 ) ;患者组血清及尿NO-3 /NO-2 水平均与平均动脉压呈显著负相关。结论 :慢性肾炎非尿毒症期患者高血压的发生可能与体内NO水平不足密切相关。
Objective:To observe the change of serum and urinary nitric oxide (NO) and the relation between NO and blood pressure in chronic glomerulonephritis (CGN) patients at pre-uremic phase.Methods:The levels of serum and urinary NO - 3/NO - 2 were measured in 92 cases of CGN at pre-uremic phase and 31 normal subjects by chemical colorimetry.Results:The levels of serum and urinary NO - 3/NO - 2 in CGN patients at pre-uremic phase were significantly lower than those in the control group.The levels of serum and urinary NO - 3/NO - 2 of the hypertension group were significantly lower than those of the normal blood pressure group and the control group;furthermore,the levels of urinary NO - 3/NO - 2 of the normal blood pressure group were significantly lower than those of the control group.There was significantly inverse correlation between the levels of serum NO - 3/NO - 2 and mean arterial pressure (MAP),and also there was significantly inverse correlation between the levels of urinary NO - 3/NO - 2 and MAP.Conclusion:In CGN patients at pre-uremic phase,hypertension may be related to the insufficiency of NO.
出处
《重庆医科大学学报》
CAS
CSCD
2003年第4期493-495,共3页
Journal of Chongqing Medical University
关键词
慢性肾小球肾炎
一氧化氮
血压
Chronic glomerulonephritis
Nitric oxide
Blood pressure
