摘要
目的 探讨瘤体局部注射As2 O3 治疗膀胱源性实体肿瘤的可行性并探讨可能的作用机制。方法 通过在小鼠局部接种肿瘤细胞建立小鼠异位移植膀胱癌 ,在瘤体局部注射As2 O3 1mmol/L 0 .2ml,连续 7d后取瘤体及肝、肾行病理检查。采用原位末端转移酶标记技术检测瘤体内肿瘤细胞的凋亡情况。结果 不同时间开始的砷剂治疗均可以使肿瘤体积缩小 ,重量减轻与对照组比较有显著差异 (P <0 .0 5 )。与对照组相比治疗组瘤体内的肿瘤细胞发生明显凋亡。结论 瘤体局部注射As2 O3 可以有效地抑制膀胱源性实体癌瘤的生长 ,其机制可能于促使肿瘤细胞凋亡有关。
Objective To explore the feasibility of arsenic trioxide injected surrounding the tumor for the treatment of solid carcinoma from bladder.Methods Arsenic trioxide was injected intratumor after establishing ectopic bladder tumor.Pathologic examination of the tumor liver and kidney were performed also including the apopotosis of tumor cell.Results After treatment the lesion was reduced in size and weight. There was significant different between treat group and control group(P< 0.05). The apopotosis rate of tumor cells in treat group was higher than that in control group.Conclusion Intratumor injection of arsenic trioxide can inhibit the growth of tumor cell by accelerating apopotosis.
出处
《肿瘤防治研究》
CAS
CSCD
2003年第4期296-297,共2页
Cancer Research on Prevention and Treatment
