摘要
目的探讨耐甲氧西林金黄色葡萄球菌 (MRSA)对常用抗生素耐药的可能原因。 方法 1993～2 0 0 0年从 4 79例病人创面中获得金黄色葡萄球菌试验菌株 5 6 0株 ,以对苯唑西林的耐药判断为耐甲氧西林金黄色葡萄球菌(MRSA)。 结果各年度MRSA的检出率高达 76 .5 % ～90 .8% ,MRSA对头孢唑啉、头孢哌酮 /舒巴坦的耐药率均较高 ,对伊米配能的耐药率呈上升趋势 ,对阿米卡星高度耐药 ,而对耐替米星的耐药率下降 ,没有发现万古霉素耐药菌株 ,发现 3株万古霉素中度敏感 (VISA)的MRSA。 结论MRSA对临床常用的β -内酰胺类抗生素及β -内酰胺类 -酶抑制剂复方抗生素耐药率很高 ,对阿米卡星高度耐药 ,而对耐替米星敏感 ,VISA的出现提示在万古霉素的选择性压力下 。
Objective To investigate the state of the resistance of methicillin resistant staphylococcus aureus (MRSA) to the antibiotics in current usage in our burn center. Methods There were 560 strains of staphylococcus aureus identified from 479 burn patients from 1993 to 2000 and the strains resistant to oxacillin among them were adjusted as MRSA. The MRSA resistant antibiotics included brizolina, sulperazon, netilmicin, amikacin ,imipenem, vancomycin with the Kirby-Bauer Disk-Diffusion method. Results The detectable rate of MRSA was from 76.5%～90.8%for investigation each year and the resis tance of MRSA was higher to amikacin, but it was sensitive to netilmicin. The resistance of MRSA to imipe nem tended to increase in the time course. It remained sensitive to vancomycin while 3 strains of vancomycin-intermediated staphylococcus aureus (VISA)were detected. Conclusion The detectable rate of MRSA was higher which it was resistant to the antibiotics in current use except netilmicin. VISA has emerged in our burn center.
出处
《上海第二医科大学学报》
CSCD
2003年第4期353-355,共3页
Acta Universitatis Medicinalis Secondae Shanghai
