摘要
Purpose: To compare the short-term efficacy and side effects of betaxolol and timoloi in treatment of primary open angle glaucoma or ocular hypertension. Methods: Fourteen patients with newly diagnosed early primary open angle glaucoma or ocular hypertension were included.Each patient received 0.5% timoloi and 0.5% betaxolol twice daily for four weeks in two phases. Between two courses of treatment there was four weeks wash out period. At the end of study the effect of these two drugs on intraocular pressure, mean arterial blood pressure,pulse rate,basic tear secretion and ocular symptoms were evaluated and statistically analyzed,using wilcoxon and chi-squar test.RESULTS:The study was performed on fourteen patients with baseline IOP of 26.7 ±1.5 mmHg.After four weeks treatmem,timoiol and betax-olol reduced IOP by 7.8±1.2mmHg or 29% and 6.1±1.3mmHg or 23%, respectively (P<0.001). The difference between two groups was significant(P<0.001). Mean arterial blood pressure was reduced with betaxolol and
Purpose: To compare the short-term efficacy and side effects of betaxolol and timoloi in treatment of primary open angle glaucoma or ocular hypertension. Methods: Fourteen patients with newly diagnosed early primary open angle glaucoma or ocular hypertension were included.Each patient received 0.5% timoloi and 0.5% betaxolol twice daily for four weeks in two phases. Between two courses of treatment there was four weeks wash out period. At the end of study the effect of these two drugs on intraocular pressure, mean arterial blood pressure,pulse rate,basic tear secretion and ocular symptoms were evaluated and statistically analyzed,using wilcoxon and chi-squar test.RESULTS:The study was performed on fourteen patients with baseline IOP of 26.7 ±1.5 mmHg.After four weeks treatmem,timoiol and betax-olol reduced IOP by 7.8±1.2mmHg or 29% and 6.1±1.3mmHg or 23%, respectively (P<0.001). The difference between two groups was significant(P<0.001). Mean arterial blood pressure was reduced with betaxolol and timoloi by 4.7±7.1mmHg (P<0. 03), and 3.2±5.6mmHg (P<0.05), respectively, but difference between two groups was not significant (P>0.1). Pulse rate was reduced with timoloi and betaxolol by 8±3.4 beats/min,and 6.5± 5.6 beats/min, respectively(P<0.01), but difference between two groups was not significant (P>0.2). Change in basic tear secretion with timoloi and betxolol was 0.8±2.1 mm/5min (P>0.2), and 0.5±1.9 mm/5min (P>0.3), respectively, and also inter-group comparison was not significant (P>0.5).85.7% of patients using betaxolol and 35.7% using timoloi complained of burning (P<0.01).The other symptoms were similar between two groups.Conclusion: In treatment of early glaucoma or ocular hypertension, it is better to be preferred timoloi over betaxolol, but both drug shoud be used with caution in patients with cardiovascular compromise.
出处
《国际眼科杂志》
CAS
2003年第1期1-1,共1页
International Eye Science
