摘要
目的 :探讨用低剂量的右美托咪定联合舒芬太尼对行妇科手术的患者实施术后镇痛治疗的临床效果。方法 :对2011年7月~2014年4月期间在我院进行妇科手术的120例患者的临床资料进行回顾性研究。我们将这120例患者随机分为A组、B组和C组,每组各有40例患者。在这三组患者手术结束后,我院使用高剂量的右美托咪定对A组患者进行术后镇痛治疗,使用低剂量的右美托咪定对B组患者进行术后镇痛治疗,联合使用低剂量的右美托咪定和舒芬太尼对C组患者进行术后镇痛治疗。手术结束48小时后,比较两组患者在T1(手术结束时)、T2(手术结束12小时后)、T3(手术结束24小时后)、T4(手术结束36小时后)和T5(手术结束48小时后)这五个时间段疼痛症状的评分以及他们发生不良反应几率。结果 :C组患者在各个时间段疼痛症状的评分均明显低于另外两组患者,组间相比差异具有显著性(P<0.05)。C组患者发生不良反应的几率明显低于另外两组患者,组间相比差异具有显著性(P<0.05)。结论 :用低剂量的右美托咪定联合舒芬太尼对行妇科手术的患者实施术后镇痛治疗效果确切,安全性高。此镇痛方法值得在临床上推广使用。
Objective: To explore the effect of dexmedetomidine combined with sufentanil for analgesia after gynecological operation. Methods: 120 cases of patients from 2011 July to 2014 April in our hospital for gynecological operation, were randomly divided into three groups, were treated with high dose dexmedetomidine; low dose dexmedetomidine; low dose of dexmedetomidine combined with sufentanyl, using the VAS pain scoring record of three set of pain, and record the adverse the nausea and vomiting, lethargy, Heartbeat bradycardia, respiratory depression incidence. Results: the three groups of patients with the VAS score at each time point were less than 4 points, T2 to T5 in 2 of VAS group were significantly higher than the 1 and 3 groups. 1 groups of nausea and vomiting rate was 50% in 2, significantly more than the 3 group; the 3 group bradycardia rate of 55% was higher than the 1 and 2 group p<0.05, with statistical significance. Conclusion: combined use of dexmedetomidine can reach a large number of sufentanil and a small amount of single drug treatment effect and the adverse reaction is less than the single drug.
