摘要
目的:观察右美托咪定在妇科腹腔镜手术术后镇痛中的效果与不良反应。方法:将80例拟行腹腔镜手术且行术后镇痛的妇科患者随机分为四组(n=20),D组(4μg/kg右美托咪定)、D加S组(2μg/kg右美托咪定加0.5μg/kg舒芬太尼)、S组(1μg/kg舒芬太尼)、N组(生理盐水),所有镇痛泵均用生理盐水稀释至48ml,手术结束放气腹时给予右美托咪定负荷剂量1μg/(kg.h)泵注15 min后连接术后镇痛泵,速度2 ml/h;观察术后2 h、6 h、12 h及24 h血压、心率、BCS舒适评分、镇静评分、呕吐及其他不良反应。结果:四组血压、心率比较差异无统计学意义(P>0.05),术后2 h、6 h BCS评分比较,N组与其他三组比较差异有统计学意义(P<0.05);三组药物镇痛组比较(除N组),D组与另两组比较差异有统计学意义(P<0.05);术后12 h和24h BCS评分比较,四组比较差异无统计学意义(P>0.05);术后2 h镇静评分比较,D组与其他三组比较差异有统计学意义(P<0.05);其余各时点比较差异无统计学意义(P>0.05);S组术后恶心、呕吐和瘙痒发生率与其他三组比较差异有统计学意义(P<0.01)。结论:右美托咪定联合舒芬太尼用于妇科腹腔镜手术术后镇痛效果确切,不良反应少。
Objective To observe the analgesic effects and adverse reactions of dexmedetomidine in gynecologic laparoscopic surger- y. Method Eighty cases scheduled for laparoscopic surgery and postoperative analgesia in gynecology patients were randomized into four groups （n = 20） , group D （4 μg/kg dexmedetomidine for postoperative analgesia）, group DS （2 μg/kg dexmedetomidine and 0. 5μg/kg sufentanil for postoperative analgesia） ,group S（ 1 μg/kg sufeutanil for postoperative analgesia） ,group N （no postoperative analgesia ） ,all analgesic pumps were diluted with saline to 48ml,in the end of surgery,dexmedetomidine infusion was given a loading dose of 1 μg/kg/h for 15mins,analgesia pump connection was used with speed 2 ml / h for 24hours. We observed blood pressure,heart rate,BCS score,seda- tion score,vomiting and other adverse reactions at 2 h ,6 h, 12 h and 24 h after operation. Results The blood pressure and heart rate was no remarkable differences in four groups. At 2h and 6h^after operation ,the BCS scores of group N was significantly higher than the other groups （P 〈0. 05）. In all of the anesthesia groups,the BCS scores of group D was significantly lower than the other groups（P 〈0. 05）. At 12 h and 24 h after operation,the BCS scores of four groups had no significant difference. At 2 h after operation,the sedation scores of group D was significantly higher than the other groups （P 〈 0. 05）. Group S had higher incidences of nausea and vomiting than other groups （P 〈 0. 01 ）. Conclusion Dexmedetomidine combined with sufentanil for postoperative analgesia in laparoscopic surgery was exact effect and less adverse reactions.
出处
《吉林医学》
CAS
2013年第25期5149-5151,共3页
Jilin Medical Journal
关键词
右美托咪定
舒芬太尼
腹腔镜
术后镇痛
Dexmedetomidine
Sufentanil
Laparoscopie
Postoperative analgesia
