摘要
高产菌株 Streptomycesavermitilis AV- h- 16 9用亚硝基胍进行处理后得到了一不产阿弗菌素的突变株 AV- m-4 81,从该突变株的发酵产物中分离纯化出化合物 AV- L- 1和 AV- L- 2。质谱和核磁共振谱等测定表明它们分别为阿弗菌素 A1 a和 A2 a的糖苷配基。
Streptomyces avermitilis AV h 169 was treated with NTG to give a mutant AV m 481 which produced several compounds different from natural avermectins. Two compounds among them, AV L 1 and AV L 2 were elucidated to be the aglycones of avermectin A 1a and A 2a , respectively by 1HNMR, 13 CNMR and MS.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第7期325-327,共3页
Chinese Journal of Pharmaceuticals
关键词
阿弗菌素
链霉菌突变株
发酵
分离
结构鉴定
avermectins
mutant strain of Streptomyces avermitilis
fermentation
separation
structure identification
