摘要
目的 :评价黄芪注射液对老年急性心肌梗死(AMI)患者左心功能的影响。方法 :92例老年AMI患者随机分为黄芪组 (4 6例 )和常规组 (4 6例 ) ,于治疗 4wk后 ,行核素心血池心室造影 ,测定左室射血分数 (LVEF)、左室峰射血率 (PER)、左室峰充盈率(PFR)及左室峰充盈率时间 (TPFR) ,以判断左室收缩与舒张功能 ;同时 ,观察两组患者梗死后心绞痛发生率 ;并于梗死 8wk后随访两组患者 ,评定NYHA心功能分级。结果 :治疗 4wk后 ,黄芪组LVEF、PER及PFR明显提高 ,TPFR缩短 (P <0 .0 5 ) ;梗死后心绞痛发生率黄芪组稍低于常规组 ,两组无统计学意义 (P >0 .0 5 )。 8wk后随访 ,NYHA心功能分级黄芪组低于常规组 ,两组比较差异显著 (P =0 .0 0 2 5 )。结论 :黄芪注射液是改善老年AMI患者心脏功能的有效药物之一。
AIM: To evaluate effects of Astragalus Injection on left cardiac function in elderly patients with acute myocardial infarction (AMI). METHODS: 92 elderly patients with AMI were randomly divided into Astragalus Injection treatment group and control group. The cardiac systolic and diastolic functions were assessed by nuclide gating cardiac blood-pool imaging in all patients after 4 wk treatment. All patients were followed up for 8th week after infarction. RESULTS: Compared with control group, left ventricular ejection fraction (LVEF), left ventricular peak ejecting rate (PER) and left ventricular peak filling rate (PFR) were higher,and left ventricular time for peck filling rate (TPFR) was shorter in treatment group. The attack rate of angina pectoris was lower slightly in treatment group, but not significantly than that in control group. NYHA classes were lower in treatment group, and the difference of NYHA class between two groups had significance (P= 0.0025 ). CONCLUSION: Astragalus Injection is an effective drug in improving left cardiac function in elderly patients with AMI.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第4期444-446,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
药效学
心肌梗死
左室功能
黄芪
pharmacodynamics
myocardium infarction
left cardiac function
Astragalus injection
